TABLE 4.1List of Proteins of Known Structure That Constitute the Validation Set

ProteinNresClassFold DescriptionName
3cti29smalldisulfide-bound fold, beta hairpin with adjacent disulfideTrypsin inhibitor from squash (Cucurbita maxima)
1ixa39smallEGF-like (disulfide-rich fold; nearly all beta)Factor IX from human (Homo sapiens)
protA47αThree-helix bundleProtein A
1gpt47smalldisulfide-bound fold, beta hairpin with adjacent disulfideGamma-thionine from barley (Hordeum vulgare)
1tfi50smallRubredoxin-like (metal-bound fold, with 2 CXXC motifs)Transcriptional factor SII from human (Homo sapiens)
6pti58smallBPTI-like (disulfide-rich α+β fold)Pancreatic trypsin inhibitor from bovine (Bos taurus)
1fas61smallSnake toxin-like (disulfide rich; nearly all beta)Fasciculin from green mamba (Dendroaspis angusticeps)
1shg62βSH3-1ike barrel (partly opened; n* = 4, S* = 8; meander)alpha-Spectrin, SH3 domain from chicken (Gallus gallus)
1cis66α+βCI-2 family (α+β sandwich; loop across free side of β)Hybrid protein from barley (Hordeum vulgare) hiproly strain
1ftz70αDNA-binding 3-helix bundle (right-handed twist; up-down)Fushi Tarazu protein from fruit fly (Drosophila melanogaster)
1pou71αDNA-binding domain (4 helices, folded leaf, closed)Oct-I POU-specific domain from human (Homo sapiens)
1c5a73αAnaphylotoxins (4 helices; irreg. array, disulfide linked)C5a anaphylotoxin from pig (Sus scrofa domestica)
3icb75αEF-hand (2 EF-hand connected with Ca bind loop)Calbindin D9K from bovine (Bos taurus)
1ubi76α+ββ-grasp (single-helix packs against β-sheet)Ubiquitin from human (Homo sapiens)
1lea84αDNA-binding 3-helix bundle (right-handed twist; up-down)LexA repressor, DNA-binding domain (Escherichia coli)
1ego85α/βThioredoxin-like (3 α/β/α layers; β-sheet order 4312)Glutaredoxin from bacteriophage t4
1hmd85αFour helical up-and-down bundle(left-handed twist)Hemerythrin from sipunculid worm (Themiste dyscrita)
1poh85α+βα+β sandwichHistidine-containing phosphocarrier proteins (Escherichia coli)
life100α+βIF3-1ike (β-α-β—α-β(2); 2 layers; mixed sheet 1243)Translation initiation factor IF3 from Escherichia coli

From: 4, The Role of Computational Biology in the Genomics Revolution

Cover of Impact of Advances in Computing and Communications Technologies on Chemical Science and Technology
Impact of Advances in Computing and Communications Technologies on Chemical Science and Technology: Report of a Workshop.
National Research Council (US) Chemical Sciences Roundtable.
Washington (DC): National Academies Press (US); 1999.
Copyright © 1999, National Academy of Sciences.

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