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Nelson HD, Huffman LH, Fu R, et al. Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2005 Sep. (Evidence Syntheses, No. 37.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

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Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility [Internet].

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Appendix Q. Evidence Table of Prophylactic Surgery Studies

*Criteria for enrollment in the high-risk category (must meet at least one of these criteria)
Two or more first-degree relatives with breast cancer
One first-degree relative and two or more second or third-degree relatives with breast cancer
One first-degree relative with breast cancer before the age of 45 years and one other relative with breast cancer
One first-degree relative with breast cancer and one or more relatives with ovarian cancer
Two second or third-degree relatives with breast cancer and one or more with ovarian cancer
One second or third-degree relative with breast cancer and two or more with ovarian cancer
Three or more second or third-degree relatives with breast cancer
One first-degree relative with bilateral breast cancer
Criteria for enrollment in the moderate-risk category
Women with a relative with breast cancer who do not meet above criteria

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