Evidence Table 3b. Quality of RCTs for long term outcomes

Author YearRandom assignment?Allocation concealed?Groups similar at baseline?Eligibility criteria specified?Outcome assessors blinded?Patient unaware of treatment?Intention to treat analysis?Maintenance of comparable groups?Reporting of attrition, crossovers, adherence, and contamination?Differential loss to follow up or high loss?Statistical analysis appropriate?Internal Validity Rating
Interferon
Bernardinello 1999219 Yes, by computerNot clarifiedYesYesNot clarifiedNot clarified, but unlikely as no placeboYesNot clarifiedNoNot reportedYesFair
Chemello 1999218 Yes, by computerNot clarifiedYesYesPathologist blinded for post treatment biopsy evaluationNot clarifiedYesNot clarifiedNoNot reportedYesFair
Nishiguchi 1995217 Yes, by computerNoYesYesNoNoYesNot clarifiedYesNoYesGood

RCT=randomized controlled trial

From: 6, Evidence Tables

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Screening for Hepatitis C Virus Infection [Internet].
Systematic Evidence Reviews, No. 24.
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