Table P

Depression/OCD/PD/PTSD studies – Atypical Antipsychotic Compared to Another Atypical Antipsychotic

Adverse EventsAtypical antipsychotic 1Atypical antipsychotic 2# of studiesAtypical antipsychotic 1Atypical antipsychotic 2Pooled OR95% CI
# adverse eventssample size# adverse eventssample size
Appetite or Weight/DecreaseRisperidoneQuetiapine101754553+Inf(0.21, Inf+ )
Appetite or Weight/DecreaseZiprasidoneOlanzapine11019222020.18(0.02, 0.87)
Appetite or Weight/IncreaseRisperidoneQuetiapine16175145530.73(0.26, 2.36)
Appetite or Weight/IncreaseZiprasidoneOlanzapine119192622024.02(2.25, 7.48)
CardiovascularZiprasidoneOlanzapine27328163352.39(0.91, 7.01)
ConstitutionalZiprasidoneOlanzapine152136391330.67(0.39, 1.15)
Constitutional/Fever or InfectionZiprasidoneOlanzapine1519202020.00(0.00, 1.42)
DermatologicZiprasidoneOlanzapine114136101330.71(0.27, 1.79)
EndocrineZiprasidoneOlanzapine16136141332.54(0.88, 8.34)
Endocrine/DiabetesQuetiapineOlanzapine139221527031.71(0.70, 5.03)
Endocrine/DiabetesRisperidoneOlanzapine1528601527033.19(1.10, 11.22)
Endocrine/DiabetesRisperidoneQuetiapine15286039221.86(0.29, 9.60)
GastrointestinalZiprasidoneOlanzapine276328573350.66(0.43, 1.00)
HEENT/BruxismZiprasidoneOlanzapine1419202020.00(0.00, 1.42)
HEENT/Decreased SalivationRisperidoneQuetiapine112175805532.30(1.20, 4.75)
HEENT/Decreased SalivationZiprasidoneOlanzapine120192322021.56(0.82, 3.01)
HemeZiprasidoneOlanzapine1313651331.73(0.33, 11.36)
MusculoskeletalZiprasidoneOlanzapine1813681331.02(0.32, 3.24)
NeuroRisperidoneQuetiapine112175705531.97(1.02, 4.09)
Neuro/HeadacheRisperidoneQuetiapine111175525531.55(0.77, 3.37)
Neuro/HeadacheZiprasidoneOlanzapine125192322021.21(0.66, 2.24)
Neuro/Movement DisorderZiprasidoneOlanzapine101925202+Inf(0.88, Inf+ )
Neuro/Movement Disorder/EPSRisperidoneQuetiapine1751752275530.92(0.64, 1.31)
Neuro/SedationRisperidoneQuetiapine1271751735532.49(1.57, 4.06)
Neuro/SensoryZiprasidoneOlanzapine1813661330.76(0.21, 2.57)
Psychiatric/AgitationRisperidoneQuetiapine13175345533.75(1.16, 19.33)
Psychiatric/AnxietyZiprasidoneOlanzapine182136641330.61(0.37, 1.02)
Psychiatric/IrritabilityZiprasidoneOlanzapine1719222020.26(0.03, 1.42)
Psychiatric/PsychoticZiprasidoneOlanzapine11519252020.30(0.08, 0.89)

NC = Not Calculated

From: Appendix E, Adverse Event Analysis

Cover of Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics
Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics [Internet].
Comparative Effectiveness Reviews, No. 6.
Shekelle P, Maglione M, Bagley S, et al.

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