Table 58Effect of adherence to and persistence with osteoporosis medications on fractures

Author, yearSample sizeStudy durationMedicationsEffect of adherence or persistence
Huybrechts, 2006286 38,1205 yearsAlendronate17% increase in fracture rate with low adherence.
Risedronate
HRT
Siris, 2006285 35,53724 monthsAlendronateRelative risk reduction 25% for all osteoporotic fractures in refill adherent patients; 29% risk reduction for non-vertebral fractures, 45% risk reduction for hip fractures in persistent patients
Risedronate
Caro,2004284 11,2495 yearsAlendronate16% decrease in fracture rate in patients with good adherence (MPR>80%)
Etidronate ± calcium
Risedronate
Calcitonin
HRT

From: 3, Results

Cover of Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis
Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis [Internet].
Comparative Effectiveness Reviews, No. 12.
MacLean C, Alexander A, Carter J, et al.

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