Table 23Studies of adults with major depressive disorders and accompanying pain

StudyInterventionsNResultsQuality Rating
Brannan et al., 2005154 Duloxetine282KQ 3a. Improvement in depression scores (P = 0.544), depression response rates (P = 0.901), and remission rates (P = 0.887) was similarFair
PlaceboKQ 3b. Improvement in pain scores was similar (P = 0.066)
Goldstein et al., 2004153 Duloxetine353KQ 3b. Improvement in pain scores was similar between active medications (P = NR), between paroxetine and placebo (P = 0.088), and between duloxetine 40 mg and placebo (P = 0.172); improvement in pain for duloxetine 80 mg was superior to placebo (P = 0.005).Poor
Paroxetine
Placebo
Detke et al., 2002155 Duloxetine245KQ 3b. Pain score improvement was slightly greater for duloxetine than placebo (P = 0.019)Fair
Placebo
Detke et al., 2002156 Duloxetine267KQ 3b. Pain score improvement was slightly greater for duloxetine than placebo (P = 0.037)Fair
Placebo
Detke et al., 200471 Duloxetine367KQ 3b. Improvement in pain scores was similar between duloxetine 80 mg and placebo (P = 0.063), and between duloxetine 120 mg and placebo (P = 0.086); improvement in pain for paroxetine was superior to placebo (P = 0.035)Fair
Paroxetine
Placebo

NR, not reported.

From: 3, Results

Cover of Comparative Effectiveness of Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression
Comparative Effectiveness of Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression [Internet].
Comparative Effectiveness Reviews, No. 7.
Gartlehner G, Hansen RA, Thieda P, et al.

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