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Humphrey LL, Johnson M, Teutsch S. Lung Cancer Screening: An Update for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2004 May. (Systematic Evidence Reviews, No. 31.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Cover of Lung Cancer Screening

Lung Cancer Screening: An Update for the U.S. Preventive Services Task Force [Internet].

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3Methods

Our review focused on the outcomes of screening in populations. We reviewed the MEDLINE and Cochrane databases from their inception through January 2003 using the search terms lung neoplasms, lung cancer, and any screening. The search strategy is detailed in Figure 1. To assure complete ascertainment, we reviewed the bibliographies of reviews, editorials, book chapters and letters discussing lung cancer screening. In addition, a recent Cochrane review and analysis41 was reviewed for studies that might have been missed. We sought studies evaluating screening in the general population, as well as in high-risk populations, and included observational studies and clinical trials. Observational studies with control groups and randomized trials evaluating disease specific mortality were evaluated for quality according to criteria created by the current USPSTF42 (Table 1). To rate each of these studies, we reviewed all related articles describing the studies but did not query study authors. We also used studies of the various screening modalities to estimate the screening test characteristics of chest x-ray (CXR) and low dose CT. Finally, we used data from the screening studies when available, as well as clinical series, to evaluate some of the harms associated with screening and subsequent treatment.

Figure 1. Search strategy for lung cancer screening.

Figure

Figure 1. Search strategy for lung cancer screening.

Table 1. U.S. Preventive Services Task Force Quality Rating Criteria.

Table 1

U.S. Preventive Services Task Force Quality Rating Criteria.

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