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Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
Mixed densely and sparsely granulated somatotroph adenoma. A proportion of somatotroph adenomas demonstrate a clearly segregated mixed densely-sparsely phenotype. The respective cells remain true to their ‘pure’ counterparts: The sparsely granulated cells can be identified as chromophobe islands amongst orangeophilic densely granulated cells (left) and their contrasting cytokeratin pattern is absolutely clear following incubation with Cam5.2 antibody (right).
From: Pathology And Pathogenesis Of Pituitary Adenomas And Other Sellar Lesions
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