FIGURE 5-1 Overview of the Metabolon process

FIGURE 5-1 Overview of the Metabolon process. Once the sample has been prepared, it is analyzed by a liquid chromatography–mass spectrometry (MS) method (with and without electrospray ionization [ESI]) and a gas chromatography–mass spectrometry method (with electron ionization). Proprietary software is used to analyze the data, and identify the molecules present in the sample and quantify their amounts.

NOTE: QA = quality assurance; QC = quality control.

SOURCE: Milburn, 2007.

From: 5, Screening Technologies III: Metabolomics

Cover of Emerging Safety Science
Emerging Safety Science: Workshop Summary.
Institute of Medicine (US) Forum on Drug Discovery, Development, and Translation.
Washington (DC): National Academies Press (US); 2008.
Copyright © 2008, National Academy of Sciences.

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