FIGURE 10.5. The LTP threshold is regulated by the AHP amplitude in aged animals.

FIGURE 10.5

The LTP threshold is regulated by the AHP amplitude in aged animals. Normally, no change is observed following 5-Hz stimulation (Figure 10.3). However, LTP is induced by treatments that reduce the AHP, such as L-channel blockade or inhibition of Ca2+ release from intracellular Ca2+ stores (Figure 10.2). (A) Time course of the synaptic response, including induction of LTP following 5-Hz pattern stimulation for aged rats during depletion of Ca2+ stores by CPA. (B) The reduction in the AHP by CPA can be reversed by application of the L-channel agonist, Bay K8644. (C) Under conditions in which the AHP is once again increased by Bay K8644, induction of LTP by 5-Hz stimulation is blocked.

From: Chapter 10, Neurophysiology of Old Neurons and Synapses

Cover of Brain Aging
Brain Aging: Models, Methods, and Mechanisms.
Riddle DR, editor.
Boca Raton (FL): CRC Press/Taylor & Francis; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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