Table 7Diagnostic odds ratios for studies that evaluated BNP and NT-proBNP in patients with symptoms suggestive of or with HF across all settings

ReportSettingTest⁁Cut point(pg/mL)SensitivitySpecificityDiagnostic Odds Ratio
Lower 95% CIUpper 95% CILower 95% CIUpper 95% CILower 95% CIUpper 95% CIn
Seino58 2004ClinicBNP(1)1350.7230.6130.8000.7310.6140.82275.5814172
NT-proBNP(9)6950.8570.7770.9110.7310.6140.82216835172
Barcarse48 2004EDBNP(2)1100.9580.8300.9800.9400.8300.97036058225798
1700.8420.7260.9140.9280.8090.975691827498
3000.7010.5730.8090.9760.8760.995961275998
Dao56 2001EDBNP(2)800.9790.9270.9940.9210.8690.9545581222250250
1000.9120.8390.9540.9410.8920.96816763441250
1150.8960.8200.9430.9600.9170.98121375607250
1200.8690.8200.9430.9600.9170.98121375607250
1500.8750.7940.9270.9700.9300.98723176705250
Logeart17 2002EDBNP(2)800.9690.9200.9880.2700.1650.41012341163
1000.9600.9080.9830.2820.1730.42510330163
1500.9300.8680.9640.4580.3250.59711528163
2000.9300.8680.9640.5620.4220.69317743163
2500.9130.8470.9520.6870.5460.80023956163
3000.8780.8060.9260.8750.753951.0005018140163
Maisel18 2002EDBNP(2)500.9700.9550.9800.6200.5860.6525434841586
800.9300.9090.9460.7390.7090.7683827521586
1000.9010.8760.9200.7600.7300.7872722381586
1250.8690.8430.8910.8900.7610.8162519331586
1500.8490.8220.8730.8300.8030.8542821361586
Morrison55 2002EDBNP(2)940.9770.9360.9920.8550.7980.89825877872321
1050.9400.8660.9690.8550.7980.8989341213321
1350.9030.8410.9420.8980.8460.9348239173321
1950.8500.7800.9010.9410.8970.9669142197321
5400.7910.7140.8510.9620.9240.9819741231321
Ray57 2004EDBNP(2)1000.9000.840.9390.5920.5170.66413725308
1500.8510.7830.9000.7120.6390.77514825308
2000.8220.7510.8760.8380.7750.886241344308
2500.7800.7040.8400.8980.8430.935311659308
3000.7320.6440.7900.9220.8710.953311561308
3500.6730.5920.7450.9220.8710.953241348308
Villacorta52 2002EDBNP(2)2000.990.881.000.960.830.99163564413570
Lainchbury7 2003EDBNP(2)690.9710.9010.9920.4370.3560.521266112205
1040.9710.9010.9920.5110.4270.594368151205
2080.9420.8620.9770.7030.6210.7743913115205
2770.8280.7230.8990.7770.70.83917836205
3460.7710.6600.8540.8370.7650.88917836205
NT-proBNP(9)11840.8710.7730.930.7110.6290.78177637205
20300.8280.7230.8990.8220.7490.877221048205
28750.8000.6910.8770.8660.7990.914261256205
37210.7420.6290.8300.9030.8420.942271259205
Bayes-Genis16 2004EDNT-proBNP(9)2540.9860.9250.9970.4670.2480.69862757287
4230.9580.8840.9850.60.3570.80135716387
5920.9440.8650.9780.80.8550.929681334387
9720.9020.8120.9520.9330.7010.98813015114287
10990.9170.830.9160.9330.7020.98815417138287
Jose 53 2003EDNT-proBNP(8)16910.9720.9050.9920.8910.7690.952291541569119
Landray66 2000Primary CareBNP(1)100.9250.8010.9740.1860.1180.2813110126
17.90.8750.7380.9450.3480.2560.4544111126
760.6750.520.7990.8720.7850.92714636126
Hobbs63 2004Primary CareBNP(1)1150.50.2370.7630.6670.5790.744217133
NT-proBNP(9)3380.9520.6670.9950.4630.3780.551171302133
Gustafsson68 2003Primary CareNT-proBNP(9)1250.9690.8460.9940.4580.4050.511274201367
Wright64 2003Primary CareNT-proBNP(6)2110.8310.7320.8980.7710.7130.82117933305

Abbreviations: HF=heart failure, ED=emergency department, CI=confidence interval

Number in bracket refers to row number in Table 1 or Table 2 describing method used to measure B-type natriuretic peptide.

From: 3, Results

Cover of Testing for BNP and NT-proBNP in the Diagnosis and Prognosis of Heart Failure
Testing for BNP and NT-proBNP in the Diagnosis and Prognosis of Heart Failure.
Evidence Reports/Technology Assessments, No. 142.
Balion C, Santaguida PL, Hill S, et al.

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