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Myers ER, Bastian LA, Havrilesky LJ, et al. Management of Adnexal Mass. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006 Feb. (Evidence Reports/Technology Assessments, No. 130.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

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Management of Adnexal Mass.

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Listing of Included Studies (alphabetical)

  1. Adonakis GL, Paraskevaidis E, Tsiga S. et al. A combined approach for the early detection of ovarian cancer in asymptomatic women. Eur J Obstet Gynecol Reprod Biol. 1996;65(2):221–5. [PubMed: 8730628]
  2. Alcazar JL, Castillo G. Comparison of 2-dimensional and 3-dimensional power-Doppler imaging in complex adnexal masses for the prediction of ovarian cancer. Am J Obstet Gynecol. 2005;192(3):807–12. [PubMed: 15746675]
  3. Alcazar JL, Errasti T, Zornoza A. et al. Transvaginal color Doppler ultrasonography and CA-125 in suspicious adnexal masses. Int J Gynaecol Obstet. 1999;66(3):255–61. [PubMed: 10580673]
  4. Alcazar JL, Galan MJ, Garcia-Manero M. et al. Three-dimensional sonographic morphologic assessment in complex adnexal masses: preliminary experience. J Ultrasound Med. 2003;22(3):249–54. [PubMed: 12636324]
  5. Alcazar JL, Lopez-Garcia G. Transvaginal color Doppler assessment of venous flow in adnexal masses. Ultrasound Obstet Gynecol. 2001;17(5):434–8. [PubMed: 11380970]
  6. Alcazar JL, Merce LT, Laparte C. et al. A new scoring system to differentiate benign from malignant adnexal masses. Am J Obstet Gynecol. 2003;188(3):685–92. [PubMed: 12634641]
  7. Anandakumar C, Chew S, Wong YC. et al. Role of transvaginal ultrasound color flow imaging and Doppler waveform analysis in differentiating between benign and malignant ovarian tumors. Ultrasound Obstet Gynecol. 1996;7:280–4. [PubMed: 8726882]
  8. Andersen ES, Knudsen A, Rix P. et al. Risk of malignancy index in the preoperative evaluation of patients with adnexal masses. Gynecol Oncol. 2003;90(1):109–12. [PubMed: 12821350]
  9. Andolf E, Jorgensen C, Astedt B. Ultrasound examination for detection of ovarian carcinoma in risk groups. Obstet Gynecol. 1990;75(1):106–9. [PubMed: 2404221]
  10. Antonic J, Rakar S. Colour and pulsed Doppler US and tumour marker CA 125 in differentiation between benign and malignant ovarian masses. Anticancer Res. 1995;15:1527–32. [PubMed: 7654041]
  11. Asif N, Sattar A, Dawood MM. et al. Pre-operative evaluation of ovarian mass: risk of malignancy index. J Coll Physicians Surg Pak. 2004;14(3):128–31. [PubMed: 15228841]
  12. Aslam N, Banerjee S, Carr JV. et al. Prospective evaluation of logistic regression models for the diagnosis of ovarian cancer. Obstet Gynecol. 2000;96(1):75–80. [PubMed: 10862846]
  13. Aslam N, Tailor A, Lawton F. et al. Prospective evaluation of three different models for the pre-operative diagnosis of ovarian cancer. BJOG. 2000;107(11):1347–53. [PubMed: 11117760]
  14. Balbi GC, Musone R, Menditto A. et al. Women with a pelvic mass: indicators of malignancy. Eur J Gynaecol Oncol. 2001;22(6):459–62. [PubMed: 11874083]
  15. Benjapibal M, Sunsaneevitayakul P, Boriboonhirunsarn D. et al. Color Doppler ultrasonography for prediction of malignant ovarian tumors. J Med Assoc Thai. 2002;85(6):709–15. [PubMed: 12322845]
  16. Benjapibal M, Sunsaneevitayakul P, Phatihattakorn C. et al. Sonographic morphological pattern in the pre-operative prediction of ovarian masses. J Med Assoc Thai. 2003;86(4):332–7. [PubMed: 12757077]
  17. Berlanda N, Ferrari MM, Mezzopane R. et al. Impact of a multiparameter, ultrasound-based triage on surgical management of adnexal masses. Ultrasound Obstet Gynecol. 2002;20(2):181–5. [PubMed: 12153670]
  18. Biagiotti R, Desii C, Vanzi E. et al. Predicting ovarian malignancy: application of artificial neural networks to transvaginal and color Doppler flow US. Radiology. 1999;210(2):399–403. [PubMed: 10207421]
  19. Bromley B, Goodman H, Benacerraf BR. Comparison between sonographic morphology and Doppler waveform for the diagnosis of ovarian malignancy. Obstet Gynecol. 1994;83(3):434–7. [PubMed: 8127538]
  20. Brown DL, Doubilet PM, Miller FH. et al. Benign and malignant ovarian masses: selection of the most discriminating gray-scale and Doppler sonographic features. Radiology. 1998;208(1):103–10. [PubMed: 9646799]
  21. Buckshee K, Temsu I, Bhatla N. et al. Pelvic examination, transvaginal ultrasound and transvaginal color Doppler sonography as predictors of ovarian cancer. Int J Gynaecol Obstet. 1998;61(1):51–7. [PubMed: 9622173]
  22. Buist MR, Golding RP, Burger CW. et al. Comparative evaluation of diagnostic methods in ovarian carcinoma with emphasis on CT and MRI. Gynecol Oncol. 1994;52(2):191–8. [PubMed: 8314138]
  23. Buy JN, Ghossain MA, Hugol D. et al. Characterization of adnexal masses: combination of color Doppler and conventional sonography compared with spectral Doppler analysis alone and conventional sonography alone. AJR Am J Roentgenol. 1996;166(2):385–93. [PubMed: 8553953]
  24. Canis M, Mage G, Pouly JL. et al. Laparoscopic diagnosis of adnexal cystic masses: a 12-year experience with long-term follow-up. Obstet Gynecol. 1994;83(5 Pt 1):707–12. [PubMed: 8164928]
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  26. Canis M, Pouly JL, Wattiez A. et al. Laparoscopic management of adnexal masses suspicious at ultrasound. Obstet Gynecol. 1997;89(5 Pt 1):679–83. [PubMed: 9166300]
  27. Carley ME, Klingele CJ, Gebhart JB. et al. Laparoscopy versus laparotomy in the management of benign unilateral adnexal masses. J Am Assoc Gynecol Laparosc. 2002;9(3):321–6. [PubMed: 12101329]
  28. Carter JR, Lau M, Fowler JM. et al. Blood flow characteristics of ovarian tumors: implications for ovarian cancer screening. Am J Obstet Gynecol. 1995;172(3):901–7. [PubMed: 7892883]
  29. Carter PG, Iles RK, Neven P. et al. The measurement of urinary beta core fragment in conjunction with serum CA125 does not aid the differentiation of malignant from benign pelvic masses. Gynecol Oncol. 1993;51(3):368–71. [PubMed: 8112647]
  30. Caruso A, Caforio L, Testa AC. et al. Transvaginal color Doppler ultrasonography in the presurgical characterization of adnexal masses. Gynecol Oncol. 1996;63(2):184–91. [PubMed: 8910625]
  31. Castillo G, Alcazar JL, Jurado M. Natural history of sonographically detected simple unilocular adnexal cysts in asymptomatic postmenopausal women. Gynecol Oncol. 2004;92(3):965–9. [PubMed: 14984967]
  32. Chalas E, Welshinger M, Engellener W. et al. The clinical significance of thrombocytosis in women presenting with a pelvic mass. Am J Obstet Gynecol. 1992;166(3):974–7. [PubMed: 1550175]
  33. Chapron C, Dubuisson JB, Capella-Allouc S. Salpingo-oophorectomy for adnexal masses. Place and results for operative laparoscopy. Eur J Obstet Gynecol Reprod Biol. 1997;73(1):43–8. [PubMed: 9175688]
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  36. Chi DS, Abu-Rustum NR, Sonoda Y. et al. Ten-year experience with laparoscopy on a gynecologic oncology service: analysis of risk factors for complications and conversion to laparotomy. Am J Obstet Gynecol. 2004;191(4):1138–45. [PubMed: 15507933]
  37. Childers JM, Nasseri A, Surwit EA. Laparoscopic management of suspicious adnexal masses. Am J Obstet Gynecol. 1996;175(6):1451–7. discussion 1457–9. [PubMed: 8987924]
  38. Chou CY, Chang CH, Yao BL. et al. Color Doppler ultrasonography and serum CA 125 in the differentiation of benign and malignant ovarian tumors. J Clin Ultrasound. 1994;22:491–6. [PubMed: 7814654]
  39. Cohen LS, Escobar PF, Scharm C. et al. Three-dimensional power Doppler ultrasound improves the diagnostic accuracy for ovarian cancer prediction. Gynecol Oncol. 2001;82(1):40–8. [PubMed: 11426960]
  40. Davies AP, Jacobs I, Woolas R. et al. The adnexal mass: benign or malignant? Evaluation of a risk of malignancy index. Br J Obstet Gynaecol. 1993;100(10):927–31. [PubMed: 8217976]
  41. Deckardt R, Saks M, Graeff H. Comparison of minimally invasive surgery and laparotomy in the treatment of adnexal masses. J Am Assoc Gynecol Laparosc. 1994;1(4 Pt 1):333–8. [PubMed: 9138874]
  42. DePriest PD, Gallion HH, Pavlik EJ. et al. Transvaginal sonography as a screening method for the detection of early ovarian cancer. Gynecol Oncol. 1997;65(3):408–14. [PubMed: 9190966]
  43. DePriest PD, Shenson D, Fried A. et al. A morphology index based on sonographic findings in ovarian cancer. Gynecol Oncol. 1993;51(1):7–11. [PubMed: 8244178]
  44. DePriest PD, van Nagell JR Jr, Gallion HH. et al. Ovarian cancer screening in asymptomatic postmenopausal women. Gynecol Oncol. 1993;51(2):205–9. [PubMed: 8276295]
  45. DePriest PD, Varner E, Powell J. The efficacy of a sonographic morphology index in identifying ovarian cancer: a multi-institutional investigation. Gynecol Oncol. 1994;55:174–8. [PubMed: 7959280]
  46. Dottino PR, Levine DA, Ripley DL. et al. Laparoscopic management of adnexal masses in premenopausal and postmenopausal women. Obstet Gynecol. 1999;93(2):223–8. [PubMed: 9932560]
  47. Dowd JR, Quinn MA, Rome R. et al. Women with a pelvic mass—when to perform an ultrasound. Aust N Z J Obstet Gynaecol. 1993;33(4):404–7. [PubMed: 8179554]
  48. Einhorn N, Bast RC Jr, Knapp RC. et al. Preoperative evaluation of serum CA 125 levels in patients with primary epithelial ovarian cancer. Obstet Gynecol. 1986;67(3):414–6. [PubMed: 2418395]
  49. Ekerhovd E, Wienerroith H, Staudach A. et al. Preoperative assessment of unilocular adnexal cysts by transvaginal ultrasonography: a comparison between ultrasonographic morphologic imaging and histopathologic diagnosis. Am J Obstet Gynecol. 2001;184(2):48–54. [PubMed: 11174478]
  50. Fanfani F, Fagotti A, Ercoli A. et al. A prospective randomized study of laparoscopy and minilaparotomy in the management of benign adnexal masses. Hum Reprod. 2004;19(10):2367–71. [PubMed: 15242993]
  51. Fenchel S, Grab D, Nuessle K. et al. Asymptomatic adnexal masses: correlation of FDG PET and histopathologic findings. Radiology. 2002;223(3):780–8. [PubMed: 12034950]
  52. Ferdeghini M, Gadducci A, Prontera C. et al. Serum soluble interleukin-2 receptor assay in epithelial ovarian cancer. Tumour Biol. 1993;14(5):303–9. [PubMed: 8235309]
  53. Ferrazzi E, Zanetta G, Dordoni D. et al. Transvaginal ultrasonographic characterization of ovarian masses: comparison of five scoring systems in a multicenter study.[erratum appears in Ultrasound Obstet Gynecol 1998 Jan;11(1):v Note: Lissoni G[corrected to Lissoni AA]] Ultrasound Obstet Gynecol. 1997;10(3):192–7. [PubMed: 9339526]
  54. Finkler NJ, Benacerraf B, Lavin PT. et al. Comparison of serum CA 125, clinical impression, and ultrasound in the preoperative evaluation of ovarian masses. Obstet Gynecol. 1988;72(4):659–64. [PubMed: 3047614]
  55. Fleischer AC, Cullinan JA, Jones HW 3rd. et al. Correlation of histomorphology of ovarian masses with color Doppler sonography. Ultrasound Med Biol. 1996;22(5):555–9. [PubMed: 8865552]
  56. Fleischer AC, Rodgers WH, Kepple DM. et al. Color Doppler sonography of benign and malignant ovarian masses. Radiographics. 1992;12(5):879–85. [PubMed: 1529130]
  57. Franchi M, Beretta P, Ghezzi F. et al. Diagnosis of pelvic masses with transabdominal color Doppler, CA 125 and ultrasonography. Acta Obstet Gynecol Scand. 1995;74(9):734–9. [PubMed: 7572110]
  58. Gadducci A, Baicchi U, Marrai R. et al. Preoperative evaluation of D-dimer and CA 125 levels in differentiating benign from malignant ovarian masses. Gynecol Oncol. 1996;60(2):197–202. [PubMed: 8631538]
  59. Gadducci A, Capriello P, Bartolini T. et al. The association of ultrasonography and CA-125 test in the preoperative evaluation of ovarian carcinoma. Eur J Gynaecol Oncol. 1988;9(5):373–6. [PubMed: 3066622]
  60. Gadducci A, Ferdeghini M, Prontera C. et al. The concomitant determination of different tumor markers in patients with epithelial ovarian cancer and benign ovarian masses: relevance for differential diagnosis. Gynecol Oncol. 1992;44(2):147–54. [PubMed: 1312052]
  61. Gadducci A, Ferdeghini M, Rispoli G, et al. Comparison of tumor-associated trypsin inhibitor (TATI) with CA125 as a marker for diagnosis and monitoring of epithelial ovarian cancer. Scand J Clin Lab Invest Suppl 1991;207(19–24). [PubMed: 1780685]
  62. Goldstein SR, Subramanyam B, Snyder JR. et al. The postmenopausal cystic adnexal mass: the potential role of ultrasound in conservative management. Obstet Gynecol. 1989;73(1):8–10. [PubMed: 2642328]
  63. Grab D, Flock F, Stohr I. et al. Classification of asymptomatic adnexal masses by ultrasound, magnetic resonance imaging, and positron emission tomography. Gynecol Oncol. 2000;77(3):454–9. [PubMed: 10831359]
  64. Granberg S, Norstrom A, Wikland M. Tumors in the lower pelvis as imaged by vaginal sonography. Gynecol Oncol. 1990;37(2):224–9. [PubMed: 2188879]
  65. Granberg S, Norstrom A, Wikland M. Comparison ofendovaginal ultrasound and cytological evaluation of cystic ovarian tumors. J Ultrasound Med. 1991;10:9–14. [PubMed: 1997688]
  66. Grover SR, Quinn MA. Is there any value in bimanual pelvic examination as a screening test. Med J Aust. 1995;162(8):408–10. [PubMed: 7746172]
  67. Guerriero S, Ajossa S, Garau N. et al. Ultrasonography and color Doppler-based triage for adnexal masses to provide the most appropriate surgical approach. Am J Obstet Gynecol. 2005;192(2):401–6. [PubMed: 15695978]
  68. Guerriero S, Ajossa S, Risalvato A. et al. Diagnosis of adnexal malignancies by using color Doppler energy imaging as a secondary test in persistent masses. Ultrasound Obstet Gynecol. 1998;11(4):277–82. [PubMed: 9618853]
  69. Guerriero S, Alcazar JL, Coccia ME. et al. Complex pelvic mass as a target of evaluation of vessel distribution by color Doppler sonography for the diagnosis of adnexal malignancies: results of a multicenter European study. J Ultrasound Med. 2002;21(10):1105–11. [PubMed: 12369665]
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