Table E-1Description of included studies (Diagnosis review)

Author, YearLocationLanguage of PublicationSIC used as Reference StandardComparison TestsSuspected Agent (molecular weight)Description of Included WorkersPatient Source
Alvarez, 2001SpainEnglishYesEosinophils, single NSBPT, skin prick, serum specific IgEFlour: oilseed rape (H)Farmers with respiratory symptoms related to fodder manipulationClinic
Alvarez, 1996SpainEnglishYesSingle NSBPT, skin prick, serum specific IgECereals (H)Bakers, millers, and farmers diagnosed with OA over a five yr periodClinic
Anees, 2004United KingdomEnglishNoSerial PFT (PEFR)Mixed (M)Consecutive workers of mixed occupation with definite OAClinic
Avery, 1969United StatesEnglishNoLymphocyte blast cell transformation, TDI-HSAIsocyanates (L)Workers exposed toTDI; some with severe symptoms at low exposure, others with less symptoms at higher exposuresNR
Balland, 1989FranceFrenchYesSingle NSBPT, serum specific IgE, serum total IgEMixed (M)Workers presenting with symptoms of suspected work-related asthma and rhinitisWorkplace
Baur, 1998GermanyEnglishYesClinical diagnosis, single NSBPTMixed (M)Healthcare workers, bakers, isocyanate workers, and hairdressers who consulted clinic because of suspected OAClinic
Baur, 1979United KingdomEnglishYesSkin prick, serum specific IgEPapain (H)Meat or pharmaceutical plant workers exposed to airborne papainOther
Behr, 1990GermanyGermanYesClinical diagnosis, single NSBPTIsocyanates (L)Workers exposed to isocyanates with workplace related respiratory symptomsClinic and workplace
Bernstein, 2002CanadaEnglishYesDi-isocyanate antigen stimulation of MCP-1, single NSBPT, serum specific IgEIsocyanates (L)Di-isocyanate exposed workers with history of OA, referred for SIC testingClinic
Biot, 1980FranceFrenchYesBasophils granules liberation, single NSBPT, serum total IgEMixed (M)Workers complaining of allergic manifestations in practicing their professionWorkplace
Block, 1983CanadaEnglishYesSingle NSBPT, skin prick, serum specific IgEFlour: wheat and rye (H)Bakers with respiratory symptoms identified from workplace survey or referred to studyClinic
Burge, 1985United KingdomEnglishYesSingle NSBPTFormaldehyde (L)Workers of mixed occupation referred for investigation of symptoms suggestive of OAClinic
Burge, 1982bUnited KingdomEnglishYesSingle NSBPTIsocyanates (L)Workers with respiratory symptoms when exposed to TDI, MDI, or colophonyNR
Burge, 1980United KingdomEnglishYesSingle NSBPTColophony (L)Electronics workers referred for investigation of respiratory symptomsClinic
Burge, 1979aUnited KingdomEnglishYesClinical diagnosis, serial PFT (PEFR)Colophony (L)Electronics factory workers who had had a bronchial provocation test by exposure to solder-flux fumes in the hospital and had kept a record of their PEFR at home and at work for at least two wksClinic
Burge, 1979bUnited KingdomEnglishYesClinical diagnosis, serial PFT (PEFR)Isocyanates (L)Workers from factories printing and laminating flexible packaging who had been admitted for SIC and had kept at least two wks of PEFR recordsClinic
Burge, 1978United KingdomEnglishYesEosinophils, single PFT, skin prickColophony (L)Electronics industry workers exposed to colophony who developed asthma or evidence of a peripheral airway reactionNR
Butcher, 1980United StatesEnglishYesSerum specific IgE, serum total IgEIsocyanates (L)Workers previously shown to give adverse bronchial reactions to SIC with TDIOther
Carletti, 1997ItalyItalianYesClinical diagnosis, single NSBPT, single PFT, skin prickFlour (H)Millers and bakers with suspected OAWorkplace
Cartier, 1989CanadaEnglishYesSerial NSBPT, single NSBPT, skin prick, serum specific IgE, serum specific IgGIsocyanates (L)Subjects of various occupations who were being investigated for possible OA caused by isocyanates who underwent SICClinic
Cartier, 1987CanadaEnglishYesSingle NSBPT, skin prick, serum specific IgEPsyllium (H)Nurses with history of asthmatic symptoms after exposure to psylliumClinic
Cartier, 1986CanadaEnglishYesSkin prick, serum specific IgESnow crab (H)Snow crab workers previously diagnosed with OAClinic
Choudat, 1999FranceEnglishYesSingle NSBPT, serum specific IgEFlour: wheat (H)Bakers and pastry makers referred for assessment of OA caused by flourClinic
Cirla, 1975ItalyItalianYesSingle NSBPT, skin prickIsocyanates (L)Furniture manufacturing workers with symptoms of asthma at workClinic
Colas, 1985FranceFrenchYesCarbon dioxide diffusion, eosinophils, single NSBPT, single PFT, skin prick, serum total IgEWood dust: exotic (L)Workers who had been hospitalized for OA due to exotic woodsClinic
Cortona, 1980ItalyItalianNoSkin prickEnzymes: bromolin (H)Workers from a pharmacuetical industry handling bromelinWorkplace
Cote, 1993CanadaEnglishYesSerial PFT (PEFR)Wood dust: cedar (L)Consecutive sawmill workers referred by family physician for work related increases in dyspnea and coughClinic
Coutts, 1984United KingdomEnglishYesSingle NSBPT, skin prickChemical: cimetidine (L)Syptomatic workers manucturing cimetidine tabletsWorkplace
Curran, 1996United KingdomEnglishNoSerum specific IgE, serum total IgEChemical: glutaraldehyde (L)Health professionals exposed to glutaraldehyde, some had been diagnosed with OA by respiratory physician, some had respiratory symptoms without diagnosisClinic
Davison, 1983United KingdomEnglishYesSkin prick, serum specific IgECastor beans (H)Merchant seamen and laboratory workers who developed allergic symptoms following exposure to castor beansWorkplace
DeZotti, 1996aItalyEnglishYesEosinophils, single NSBPT, single PFT, skin prickWood dust: exotic (L)Furniture manufacturers and wood processors complaining of respiratory symptoms at workClinic
DeZotti, 1996bItalyItalianYesEosinophils, single NSBPT, single PFT, skin prick, serum specific IgEMixed (M)Workers with OA due to isocyanate or wheat exposureClinic
Dellabianca, 1996ItalyEnglishYesSingle NSBPT, single NSBPTMixed (M)Consecutive subjects of mixed occupation referred to clinic for probable OA due to low molecular weight chemicals- both SIC reactors and non-reactorsClinic
Dente, 1986ItalyEnglishYesSingle NSBPTIsocyanates (L)Workers with occupational exposure to TDINR
DiFranco, 1998ItalyEnglishYesEosinophils, single NSBPTMixed (M)Workers with OA induced by low or high molecular weight compounds seen in a clinic over a two yr periodClinic
DiStefano, 1999United KingdomEnglishNoSingle NSBPT, skin prickChemical: glutaraldehyde (L)Health care workers with symptoms suggestive of OA due to exposure to glutaraldehydeOther
Duan, 1989ChinaChineseYesClinical diagnosis, serial NSBPT, serial PFT, single PFT, skin prick, serum specific IgEIsocyanates (L)Symptomatic TDI factory workers compared to non-symptomatic workers and ordinary asthma workersMixed
Ferguson, 1996CanadaEnglishYesSingle NSBPT, single PFT, serum specific IgEIsocyanates (L)Auto manufacturers and spray painters with chest symptoms compatible with asthma and prior exposure to isocyanatesOther
Gannon, 1996United KingdomEnglishNoSerial PFT (PEFR)Mixed (M)Records from workers from different industries attending an occupational lung disease clinic with suspected OA, and from a cross sectional survey of respiratory symptoms in post office sorting workersMixed
Girard, 2004CanadaEnglishYesEosinophils, serial NSBPT, serial PFT, skin prickMixed (M)Subjects referred to OA reference centres for possible OAClinic
Graneek, 1987United KingdomEnglishYesSingle NSBPTMixed (M)Workers from various industries who were admitted to hospital for investigation of OAOther
Grosclaude, 1980FranceFrenchYesSingle NSBPT, skin prick, serum total IgEMixed (M)Workers of mixed occupation with OA due to various causesWorkplace
Harries, 1980United KingdomEnglishYesEosinophils, skin prickMixed (M)Workers of various occupation with a history of respiratory illness worsening at workClinic
Hinojosa, 1986SpainEnglishYesSkin prick, serum specific IgE, serum total IgEWood dust: African maple and ramin (L)Workers exposed to African maple dust who were admitted for study after being away from work for at least two wksClinic
Howe, 1983United KingdomEnglishYesSkin prick, serum specific IgEChemical: TCPA (L)Factory workers with respiratory symptoms referred by factory managementWorkplace
Huggins, 2003United KingdomEnglishNoSerial PFT (PEFR)Enzymes: detergent (H)Factory workers with work-related respiratory symptoms and positive serum specific IgE or skin prick tests to one of the enzymes used in biological detergentsClinic and workplace
Jager, 1993GermanyGermanYesSingle NSBPT, skin prick, serum specific IgE, supervised work challenge, serum total IgELatex (H)Health care workers with an immediate allergic-type reaction to latex glovesClinic
Karol, 1994United StatesEnglishYesClinical diagnosis, single NSBPT, serum specific IgE, serum specific IgG, serum total IgEIsocyanates (L)Workers with a history of sensitization to isocyanates, referred for evaluation of respiratory symptomsClinic
Kern, 1991United StatesEnglishNoSingle NSBPTChemical: glacial acetic acid (L)Hospital laboratory and radiology workers exposed to a one time spill of 100% acetic acid for two and a half hrsWorkplace
Keskinen, 1988FinlandEnglishYesSkin prick, serum specific IgEIsocyanates (L)Workers of mixed occupation with verified asthma due to di-isocyanates based on symptoms and SICClinic
Kim, 1999KoreaEnglishYesSingle NSBPT, single PFT, skin prick, serum specific IgE, serum total IgECitrus red mite (H)Citrus fruit farmers with respiratory symptomsClinic
Kim, 1997KoreaEnglishNoSingle PFT, serum specific IgE, serum specific IgGIsocyanates (L)Workers who had been exposed to TDI in workshops manufacturing furniture or musical instruments or repairing motor vehiclesWorkplace
Kongerud, 1992NorwayEnglishNoClinical diagnosis, eosinophils, serial NSBPT, single NSBPT, symptom score, serum total IgEPotroom (L)Potroom workers with a history suggestive of OA after standardized interview and methacholine challenge PC20 <32 g/LClinic
Kopferschmitt-Kubler, 1998FranceEnglishYesSerial PFT (FEV1), single NSBPTIsocyanates (L)Workers with clinical history of isocyanate-induced asthma with reversibility and no positive reaction to low doses of TDIClinic
Koskela, 2003Australia and FinlandEnglishYesExhaled nitric oxide, single NSBPT, skin prick, serum specific IgE, serum total IgEAnimal/bird: cow dander (H)Dairy farmers who were referred to the laboratory because of a suspicion of OA due to bovine allergensClinic
Krakowiak, 2003PolandEnglishYesClinical diagnosis, eosinophils, single NSBPT, skin prick, serum specific IgEAnimal/bird: lab animals (H)Laboratory animal workers referred to an occupational disease clinic for asthma and allergic rhinitisClinic
Lam, 1979CanadaEnglishYesSingle NSBPT, skin prickWood dust: cedar (L)Subjects with OA that were tested while symptomatic or after removed from exposureClinic
LaPaglia, 1986ItalyItalianYesClinical diagnosis, skin prickMixed (M)Subjects with a work-associated respiratory diseaseClinic
Larbanois, 2003BelgiumEnglishYesSerial PFT (sGaw), single NSBPTMixed (M)Consecutive subjects of various occupations who were investigated for OA and underwent SICClinic
Lemiere, 2001CanadaEnglishYesEosinophils, single NSBPT, skin prickMixed (M)Workers of various occupations referred to clinic for possible OA and subjects who had a diagnosis of asthma (concentration of methacholine inducing a 20% fall in FEV1 of less than 8mg/mL and who could produce sputum)Clinic
Liss, 1991CanadaEnglishYesSerial PFT (PEFR), single NSBPT, single PFT, skin prickMixed (M)Consecutive workers with mixed occupations referred for assessment of possible OAClinic
Lozewicz, 1985United KingdomEnglishYesSingle NSBPT, skin prickChemical: acrylates (L)Subjects with asthma associated with exposure to cyanoacrylatesNR
Malo, 1993aCanadaEnglishYesSerial PFT (PEFR)Mixed (M)Workers of mixed occupation referred for investigation of possible OAClinic
Malo, 1991CanadaEnglishYesQuestionnaire, serial NSBPT, serial PFT (PEFR), single NSBPT, skin prickMixed (M)Workers of mixed occupation referred because of possible OAClinic
Malo, 1990CanadaEnglishYesSingle NSBPT, skin prickMixed (M)Records of subjects with late asthmatic reactions and isolated immediate reactions to SICClinic
Malo, 1988aCanadaEnglishYesEosinophils, questionnaire, serial PFT (PEFR), single NSBPT, skin prickSpiromycin (L)All workers in a pharmaceutical company, intermittently exposed to spiromycin, investigated to determine frequency of OAWorkplace
Mapp, 1986ItalyEnglishYesSingle NSBPT, skin prickIsocyanates (L)Subjects with sensitivity to TDINR
Mapp, 1979ItalyItalianYesSingle NSBPT, skin prickIsocyanates (L)Employees who worked in paint, varnish and plastics manufacturing with chronic respiratory symptoms at workWorkplace
Merget, 1997GermanyEnglishYesSingle NSBPT, skin prick, serum specific IgE, serum total IgEFlour: wheat (H)Highly selected bakers referred to clinic for assessment of OAClinic
Merget, 1996GermanyEnglishYesSingle NSBPT, skin prick, serum total IgEChemical: platinum salts (L)Platinum refinery and catalyst production workers who were considered to have OA due to platinum saltsClinic
Merget, 1993GermanyEnglishYesSingle NSBPT, skin prick, serum specific IgE, serum total IgEEnzymes (H)Enzyme manufacturing plant workers referred to the pulmonary department with work related symptomsWorkplace
Mole, 1977ItalyItalianNoSingle NSBPT, skin patch testMixed (M)Workers of many occupations with suspected OAClinic
Moller, 1986United StatesEnglishYesClinical diagnosis, single NSBPT, single PFTIsocyanates (L)Workers of various occupations referred for possible TDI asthma based on consistent clinical and occupational historyClinic
Moller, 1985United StatesEnglishNoEosinophils, questionnaire, serial PFT (FEV1), serum specific IgEChemical: hexahydrophthalic anhydride (L)Workers in a plant manufacturing bushings for electrical transformers who reported symptoms of asthmaWorkplace
Moscato, 1993ItalyEnglishYesSingle NSBPTs, single PFT, skin prickIsocyanates (L)Workers in furniture and plastics industries, auto body repair workers, and carpenters referred for probable OA due to TDIClinic
Munoz, 2004SpainEnglishYesSerial PFT (PEFR), single NSBPT, skin prick, serum total IgEChemical: persulfate (L)Hairdressers and cosmetic industry workers exposed to hair bleaches diagnosed with OAClinic
Nielsen, 1988SwedenEnglishNoSingle NSBPT, skin prick, serum specific IgE, serum specific IgG, serum total IgEChemical: phthalic anhydride (L)Workers from factories producing polyester resins reporting asthma symptoms during exposureWorkplace
Nordman, 1985FinlandEnglishYesEosinophils, serial PFT (PEFR), single NSBPT, single PFT, serum total IgEFormaldehyde (L)Workers with various occupations investigated because of suspected formaldehyde-induced asthmaClinic
O'Brien, 1979aUnited KingdomEnglishYesSingle NSBPTIsocyanates (L)Subjects referred for investigation of possible work related respiratory symptomsClinic
O'Brien, 1979bUnited KingdomEnglishYesExercise test, single NSBPT, skin prickIsocyanates (L)Workers occupationally exposed to TDI referred for investigation of possible work related asthma symptomsClinic
Obata, 1999CanadaEnglishYesEosinophils, exhaled nitric oxide, single NSBPT, skin prickWood dust: cedar (L)Sawmill workers or carpenters referred to respiratory clinic with symptoms of cough, wheeze and chest tightness after working with red cedar for at least six mosClinic
Obtulowicz, 1998PolandEnglishYesEosinophils, skin prick, serum total IgEMixed (M)Steel and tobacco factory workers with bronchial asthma suspected to be of occupational originOther
Paggiaro, 1987bCanadaEnglishYesSingle NSBPT, skin prick, serum specific IgEWood dust: cedar (L)Workers with OA due to western red cedarClinic
Paggiaro, 1986ItalyEnglishYesSingle NSBPT, skin prickIsocyanates (L)Furniture industry workers with OA induced by TDIClinic
Paggiaro, 1984bItalyItalianYesSingle NSBPT, skin prick, serum specific IgE, serum total IgEEnzymes: proteolytic (H)Workers in a factory producing detergents with symptoms of OAWorkplace
Paggiaro, 1984cItalyItalianYesClinical diagnosis, single NSBPTIsocyanates (L)Workers from a furniture industry exposed to isocyanatesWorkplace
Paggiaro, 1981ItalyEnglishYesSingle NSBPT, skin prick, serum specific IgEWood dust: tanganyika aningre (L)Woodworkers exposed to tanganyika aningre with symptoms of dyspnea, cough, and wheezingOther
Palczynski, 2003PolandEnglishYesEosinophils, single NSBPT, skin prick, serum specific IgE, serum total IgEChloramine (L)Healthcare workers with a history of respiratory symptoms related to chloramine TOther
Park, 2002bKoreaEnglishYesImmunoblotting, single NSBPT, skin prick, serum specific IgEAlpha amylase (H)Nurses with asthma symptoms when exposed to porcine pancreatic extracts at workClinic
Park, 2001KoreaEnglishYesSkin prick, serum specific IgEReactive dyes (L)Workers with OA from reactive dyes (SIC positive) who visited clinic in last ten yrs, asymptomatic workers in a reactive dye factory, and unexposed subjects with negative SIC to reactive dyesMixed
Park, 1999KoreaEnglishYesSingle NSBPT, single PFT, skin prick, serum specific IgEIsocyanates (L)Workers with TDI induced asthma, as well as SIC negative workers and control subjects with allergic asthmaOther
Park, 1998KoreaEnglishYesEosinophils, immunoblotting, single NSBPT, skin prick, serum specific IgEGrain dust (H)Animal feed industry workers exposed to grain dustWorkplace
Park, 1994KoreaEnglishYesSerial PFT (PEFR), single NSBPT, skin patch test, skin prickChemical: chromium (L)Metal plating factory, cement manufacturers and construction workers complaining of work related symptomsClinic
Park, 1991KoreaEnglishYesSingle NSBPT, skin prick, serum specific IgE, serum total IgEReactive dyes (L)Symptomatic textile dye industry workers with bronchial hyperreactivityWorkplace
Park, 1989KoreaEnglishYesSingle NSBPT, single PFT, skin prick, serum specific IgEReactive dyes (L)Dye process workers who complained of asthmatic symptoms following various lengths of exposure to reactive dyesWorkplace
Perrin, 1990CanadaEnglishYesSerial NSBPT, serial PFT (PEFR)Mixed (M)Subjects referred for OA to various agentsClinic
Pezzini, 1984ItalyEnglishYesSingle NSBPT, skin prick, serum specific IgEIsocyanates (L)Polyurethane foam shoe factory and furniture plant workers with diagnosis of isocyanate-induced OA based on symptoms and SICNR
Prichard, 1984AustraliaEnglishNoSingle NSBPT, skin prickFlour: wheat (H)Bakers and bakery workers of fulfilled the definition of work related asthmaWorkplace
Quirce, 2000SpainEnglishNoSkin prick, serum specific IgEWood dust: obeche (L)Woodworkers with symptoms of asthma after exposure to obeche wood dustNR
Quirce, 1992SpainEnglishYesSingle NSBPT, skin prick, serum specific IgEAlpha amylase (H)Bakers evaluated in clinic because of respiratory symptoms due to exposure to flours and enzymes at workClinic
Rasanen, 1994FinlandEnglishYesBasophil histamine release, skin prick, serum specific IgE, serum total IgEMixed (M)Workers of mixed occupation with challenge-proven occupational rhinitis or asthma and workers with seasonal rhinitis or other respiratory symptomsNR
Redlich, 1996United StatesEnglishYesBronchial alveolar lavage, eosinophils, single NSBPTIsocyanates (L)Currently exposed workers with isocyanate asthmaNR
Ricciardi, 2003ItalyEnglishYesEosinophils, serial PFT (PEFR), single NSBPT, skin prick, serum specific IgE, serum total IgEWood dust: iroko (L)Wood workers who reported asthma symptomsClinic
Sander, 2001GermanyGermanYesSkin prickFlour: wheat and rye (H)Bakers with asthma symptomsNR
Sastre, 2003SpainEnglishYesSingle NSBPT, serum specific IgEIsocyanates (L)Workers with a suspected clinical history of di-isocyanate-induced asthmaOther
Schuermans, 2003BelgiumEnglishYesSingle NSBPTLatex (H)Workers of unreported occupation referred to centre for suspected latex OAClinic
Schwaiblmair, 1997GermanyEnglishYesSingle NSBPT, single PFT, skin prickBleaching powder (L)Hairdressers who had regular contact with various hair products and a clinical history of job related rhinitic/asthma symptomsClinic
Schwarting, 1979GermanyGermanYesClinical diagnosis, skin prick, serum specific IgEFlour (H)Bakers who were exposed to flour dust for at least eight hrs per dayWorkplace
Shirai, 2003JapanEnglishYesClinical diagnosis, single NSBPT, skin prickGreen tea (L)Green tea factory workers with clinical history suggestive of asthma referred to Internal Medicine and associated hospitalsClinic
Shirakawa, 1988JapanEnglishYesAntibodies (CO-HSA), eosinophils, single NSBPT, skin prick, serum specific IgEChemical: cobalt (L)Hard metal plant workers who met clinical criteria for OAClinic
Slovak, 1981United KingdomEnglishNoSerial PFT (PEFR), skin prickChemical: AZO dicarbonamide (L)Personnel with positive history of wheezing or chest tightness (+/- cough) related to exposure to azodicarbonamide dust on screening at a manufacturing plantWorkplace
Symington, 1981United KingdomEnglishYesSkin prickMushroom dust (H)Food manufacturing workers presenting with work related symptoms to dried mushroom dustWorkplace
Tabar, 2004SpainEnglishYesImmunoblotting, skin patch test, skin prick, serum specific IgE, serum total IgEAsparagus (H)Workers with various occupations diagnosed with asparagus allergy in the past five yrsClinic
Taivainen, 1994FinlandFinnishYesClinical diagnosis, skin prick, serum specific IgEAnimal/bird: cow dander (H)Farmers refered to a clinic for investigation of OAClinic
Tee, 1998United KingdomEnglishNoSkin prick, serum specific IgEIsocyanates (L)All workers exposed to isocyanates who were referred for investigation of OA from whom blood was available for measurement of serum specific IgE and in whom a firm diagnosis was reachedClinic
Tse, 1982CanadaEnglishYesSerum specific IgEWood dust: cedar (L)Workers suspected to have red cedar asthma who were referred to the clinic to undergo antigenic bronchoprovocation test to have the diagnosis confirmedClinic
Vandenplas, 2001BelgiumEnglishYesClinical diagnosis, serial NSBPT, single NSBPT, skin prickLatex (H)Consecutive workers who were referred for the investigation of possible OA and who were exposed at work to airborne allergens from natural rubber latex glovesClinic
Vandenplas, 1995bBelgiumEnglishYesSingle NSBPT, skin prickLatex (H)Hospital employees (nurses, lab technologists, cleaning staff) exposed to latexWorkplace
Vanhanen, 2000FinlandEnglishYesSingle NSBPT, skin prick, serum specific IgECellulase (H)Workers with suspected OA or rhinitis due to cellulase who were referred to a clinicClinic
Virtanen, 1996FinlandEnglishNoSerum specific IgE, serum specific IgGAnimal/bird: cow dander (H)Randomly selected dairy farmers diagnosed with cow asthma who were workers of the pulmonary clinicClinic
Vogelmeier, 1991GermanyEnglishYesSingle NSBPT, skin prick, serum specific IgEIsocyanates (L)Workers who had occupational contact with TDI and/or MDI and a strong clinical history or workplace-related asthma and normal volunteers; subjects with asthma and no isocyanate exposureNR
Wurzinger, 1997AustriaGermanYesSingle NSBPT, skin prick, serum specific IgE, serum total IgEFlour (H)Cooks, bakers, farmers, and confectioners with suspected OAClinic
Zeiler, 2002FinlandEnglishYesSingle NSBPT, skin prick, serum specific IgE, serum specific IgGAnimal/bird: cow dander (H)Consecutive dairy farmers referred to pulmonary clinic for confirmation of the bovine origin of their OAClinic
Zeiss, 1977United StatesEnglishNoSkin prick, serum specific IgE, serum specific IgGChemical: trimellitic anhydride (L)Chemical plant workers with asthma and/or rhinitis symptoms due to TMA exposureClinic

Abbreviations: AC = azodicarbonamide; CO-HSA = conjugated human serum; FEV 1 = forced expiratory volume in one second; H = high; L = low; M = mixed; MCP-1 = monocyte chemoattractant protein-1; MDI = diphenylmethane di-isocyanate; mos = months; NR = not reported; NSBPT = non-specific bronchial provocation; OA = occupational asthma; PC 20 = provocative concentration causing a 20% drop in FEV1; PEFR = peak expiratory flow rate; PFT = pulmonary function test; sGaw = specific airways conductance; SIC = specific inhalational challenge; TCPA = tetrachlorophthalic anhydride; TDI-HSA = toluene di-isocyanates human serum albumin; TMA = trimellitic anhydride; wks = weeks; yr = year; yrs = years

From: Appendix E: Evidence Tables

Cover of Diagnosis and Management of Work-Related Asthma
Diagnosis and Management of Work-Related Asthma.
Evidence Reports/Technology Assessments, No. 129.
Beach J, Rowe BH, Blitz S, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.