Evidence Table 3a.1. Characteristics of Studies on the Relation of Depression to Biomarkers in Patients After Myocardial Infarction (Question 3a)

Study Author, YearStudy DesignTarget PopulationExclusion CriteriaNumber of Study SitesStudy SiteRecruitment PeriodStudy Objective
Carney, 2001 Pro cohort a Only MI b patientsActive suicidal ideation, h/o c of alcoholism/substance, cognitively impaired, life threatening medical illness, severe psychiatric disorder, physically unable to complete the interview, lived too far away, atrial fibrillation or flutter, implanted pacemakerMulticenter,4USAOct 1997 - Jan 2000To determine if depression is associated with reduced heart rate variability in patients with a recent MI.
Kuijpers, 2002 Pro cohortOnly MI patientsPrevious MINR d EuropeNRTo investigate whether platelet function is increased in depressed patients with first MI using PF 4 e and B-TG f as markers compared with a group of non-depressed post-MI patients matched for age, sex, and size of MI.
Lesperance, 2004 Pro cohort481 patients with ACS g 81.7% with MI Data for MI not reported seperately.Terminally ill < 2 years, cognitively impaired, non French speaking, ACS secondary to medical illness, too far from intervention site, using antibioticsMulticenter,2CanadaAug 1999 - Aug 2001To determine whether or not depression is associated with higher levels of inflammatory markers in patients recovering from acute coronary syndromes.

Prospective cohort study


Myocardial infarction


History of


Not reported


Platelet factor 4




Acute coronary syndrome

From: Appendix G. Evidence Tables

Cover of Post-Myocardial Infarction Depression
Post-Myocardial Infarction Depression.
Evidence Reports/Technology Assessments, No. 123.
Bush DE, Ziegelstein RC, Patel UV, et al.

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