Evidence Table C.2.2. Evidence table of clinical trials of the clinical effects of omega-3 fatty acids on clinical outcomes after cancer treatment

First Author, YearOutcomesApplicability
ResultsFunding Source
Quality
Braga, 200264 Postoperative complications:Applicability: IIB
RR: 0.35 (95% CI 0.19, 0.67)Funding source: NR
Length of stay:Jadad: 3
Mean difference: -2.5 days (95% CI -3.5, -3.5)Concealment of allocation: NR
Mortality:
Placebo: 1/10
O-3: 1/100
Nutrition: NR
Mean weight loss: NR
Braga, 200265 Postoperative complications:Applicability: IIB
RR: 0.54 (95% CI 0.27, 1.13)Funding source: NR
Length of stay:Jadad: 3
Mean difference: -2.7 days (95% CI -4.0, -1.4)Concealment of allocation: NR
Mortality:
Placebo: 1/10
O-3: 2/50
Nutrition: NR
Mean weight loss: NR
Braga, 199566 Postoperative complications:Applicability: IIB
RR: 0.46 (95% CI 0.09, 2.30)Funding source: NR
Length of stay:Jadad: 2
Mean difference: -1.7 days (95% CI -4.5, -1.0)Concealment of allocation: NR
Mortality: NR
Nutrition: NR
Mean weight loss: NR
Braga, 199967 Postoperative complications:Applicability: IIB
RR: 0.43 (95% CI 0.21, 0.89)Funding source: NR
Length of stay: NRJadad: 4
Mortality: NRConcealment of allocation: NR
Nutrition:
Caloric intake kcal/dayNitrogen intake g/dayAlbumin md/dlTransferrin mg/dlPrealbumin mg/dl
PlaceboNRNR3.721818
O-3NRNR3.722323
Reported TestingNRNRNRNRP<0.05
Mean weight loss: NR
Daly, 199268 Postoperative complications:Applicability: IIB
RR: 0.38 (95% CI 0.13, 1.07)Funding source: Government, private, industry
Length of stay:Jadad: 1
Mean difference: -6.0 days (95% CI -7.09, -4.91)Concealment of allocation: Y
Mortality:
Placebo: 0/41
O-3: 1/36
Nutrition:
Caloric intake kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
Placebo128592.0152NR
O-3142115.62.1161NR
Reported TestingNRp=0.001NRNRNR
Mean weight loss: NR
Daly, 199569 Postoperative complications:Applicability: IIB
RR: 0.23 (95% CI 0.07, 0.73)Funding source: NR
Length of stay:Jadad: 1
Mean difference: -4.4 days (95% CI -7.85, -0.95)Concealment of allocation: Y
Mortality: NR
Nutrition:
Caloric intake kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
Placebo123210.13.118117
O-3106711.93.119016
Reported TestingNRNRNRNRNR
Mean weight loss: NR
Di Carlo, 199970 Postoperative complications:Applicability: IIB
RR: 0.53 (95% CI 0.14, 1.95)Funding source: NR
Length of stay:Jadad: 1
Mean difference: -1.5 days (95% CI -4.6, -1.6)Concealment of allocation: NR
Mortality:
Placebo: 1/33
O-3: 0/35
Nutrition:
Caloric intake kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
Placebo1550NRNRNRNR
O-31580NRNRNRNR
Reported TestingNRNRNRNRNR
Mean weight loss: NR
Fearon, 200376 Postoperative complications: NRApplicability: IIB
Length of stay: NRFunding source: Industry
Mortality:Jadad: 5
Placebo: 11/105Concealment of allocation: Y
O-3: 16/95
Nutrition: NR
Mean weight loss:
Placebo: 0.37 kg/month
O-3: 0.25 kg/month
Gianotti, 199977 Postoperative complications: NRApplicability: IIB
Length of stay: NRFunding source: NR
Mortality: NRJadad: 4
Nutrition:Concealment of allocation: NR
Caloric intake kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
PlaceboNRNR3.7NR18
O-3NRNR3.7NR26
Reported TestingNRNRNRNR<0.05
Mean weight loss: NR
Gianotti, 199771 Postoperative complications:Applicability: IIB
RR: 0.2365(95% CI 0.35, 1.22)Funding source: NR
Length of stay:Jadad: 2
Mean difference: -3.5 days (95% CI -5.2, -1.0)Concealment of allocation: NR
Mortality:
Placebo: 2/77
O-3: 3/77
Nutrition:
Caloric intake kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
PlaceboNRNRNRNR18
O-3NRNRNRNR23
Reported TestingNRNRNRNRp<0.01
Mean weight loss: NR
Heller, 200475 Postoperative complications: NRApplicability: IIB
Length of stay:Funding source:
Mean difference: 0 days (95% CI -25, 25)Industry
Mortality: NRJadad: 5
Nutrition: NRConcealment of allocation: Yes
Mean weight loss:
Placebo: 1.1 ± 2.2 kg over length of hospital stay
O-3: 0.0 ± 2.9 kg over length of hospital stay
No significant difference between groups
Kenler, 199661 Postoperative complications:Applicability: IIB
RR: 0.91 (95% CI 0.38, 2.16)Funding source: Industry
Length of stay:Jadad: 1
Mean difference: 0.7 days (95% CI -2.80, 4.20)Concealment of allocation: NR
Mortality:
Placebo: 1/18
O-3: 1/17
Nutrition:
Caloric intak kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
Placebo1050NRNRNRNR
O-31102NRNRNRNR
Reported Testingp = 0.63NRNRNRNR
Mean weight loss: NR
McCarter, 199862 Postoperative complications: NRApplicability: IIB
Length of stay:Funding source: Industry
Mean difference: 2.0 days (95% CI -7.45, 11.45)Jadad: 4
Mortality: NRConcealment of allocation: NR
Nutrition: NR
Mean weight loss: NR
Preshaw, 197979 Postoperative complications: NRApplicability: NR
Length of stay: NRFunding source: RN
Mortality: NRJadad: 0
Nutrition: NRConcealment of allocation: NR
Mean weight loss:
Placebo: 2.5 kg over 2 weeks
O-3: 3.9 kg over 2 weeks
Schilling, 199672 Postoperative complications:Applicability: IIB
RR: 0.50 (95% CI 0.15, 1.61)Funding source: Industry
Length of stay:Jadad: 2
Mean difference: 0.5 days (95% CI -7.5, 8.5)Concealment of allocation: NR
Mortality: NR
Nutrition:
Caloric intake kcal/kg/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
Placebo30.4NRNRNRNR
O-317.4NRNRNRNR
Reported TestingNRNRNRNRNR
Mean weight loss: NR
Senkal, 199774 Postoperative complications:Applicability: IIB
RR: 0.71 (95% CI 0.41, 1.21)Funding source: NR
Length of stay:Jadad: 3
Mean difference: -3.6 days (95% CI -4.5, -2.7)Concealment of allocation: NR
Mortality: NR
Nutrition: NR
Mean weight loss: NR
Senkal, 199973 Postoperative complications:Applicability: IIB
RR: 0.54 (95% CI 0.27, 1.10)Funding source: NR
Length of stay:Jadad: 3
Mean difference: -3.6 days (95% CI -4.9, -2.4)Concealment of allocation: NR
Mortality: NR
Nutrition: NR
Mean weight loss: NR
Swails, 199763 Postoperative complications:Applicability: IIB
RR: 1.67 (95% CI 0.52, 5.39)Funding source:
Length of stay: NRJadad: 2
Mortality:Concealment of allocation: NR
Placebo: 0/10
O-3: 0/8
Nutrition:
Caloric intake kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
Placebo1047NRNRNRNR
O-31010NRNRNRNR
Reported TestingNRNRNRNRNR
Weight: NR
Vignali, 199578 Postoperative complications: NRApplicability: IIIB
Length of stay: NRFunding source: NR
Mortality: NRJadad: 2
Nutrition:Concealment of allocation: NR
Caloric intake kcal/dayNitrogen intake g/dayAlbumin mg/dlTransferrin mg/dlPrealbumin mg/dl
PlaceboNRNR3.2NR17
O-3NRNR3.4NR20
Reported TestingNRNRNRNRNR
Weight: NR
*

NR = not reported, O-3 = omega-3, g = gram, kcal = kilocalories, mg = milligrams, dl = deciliter, kg = kilograms;

† mean values.

From: Appendix C. Evidence Tables

Cover of Effects of Omega-3 Fatty Acids on Cancer
Effects of Omega-3 Fatty Acids on Cancer.
Evidence Reports/Technology Assessments, No. 113.
MacLean CH, Newberry SJ, Mojica WA, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.