Evidence Table 1. ACE Inhibitor-Accepted Articles

Author, DateDrug StudiedSampleFollowupData reported for specific subpop/comorbData may be at patient level for specific subpop/ comorbStudy name
CHF Defined
Study population
(Pitt B, 1992)enalapril6797NRNRBlack patientsSOLVD
Systolic dysfunctionVery old (Age 80+) patients
Both sympt and asympt patientsNursing home patients
(Yusuf S, 1992)enalapril4228NRDiabetic patientsBlack patientsSOLVD
Systolic dysfunctionFemale patients
Post MI and reduced LVEF
(The SOLVD Investigators, 1991)enalapril2569NRNRBlack patientsSOLVD
Systolic dysfunctionDiabetic patients
Symptomatic patients
(Moye LA, 1994)captopril22312 yrBlack patientsNo subpopulationsSAVE
Systolic dysfunctionFemale patients
Asymptomatic patientsDiabetic patients
(Pfeffer MA, 1992)captopril2231NRNRVery old (Age 80+) patientsSAVE
Systolic dysfunctionFemale patients
Post MI and reduced LVEFDiabetic patients
(Ball SG, 1993)ramipril2006NRNRFemale patientsAIRE
CHF unspecifiedDiabetic patients
Symptomatic patients
(Cleland JG, 1997)ramipril2006NRNRNo subpopulationsAIRE
CHF unspecified
Symptomatic patients
(Exner DV, 2000)enalapril1996NRBlack patientsNRSOLVD
Systolic dysfunction
Symptomatic patients
(Exner DV, 2001)enalapril1996NRBlack patientsNo subpopulationsSOLVD
Systolic dysfunction
Both sympt and asympt patients
(Kober L, 1995)trandolapril1749NRNRVery old (Age 80+) patientsTRACE
Systolic dysfunctionFemale patients
Symptomatic patientsDiabetic patients
(Torp-Pedersen C, 1996)trandolapril1749NRDiabetic patientsFemale patientsTRACE
Systolic dysfunctionRenal failure patients
Symptomatic patients
(Ambrosioni E, 1995)zofenopril1556NRDiabetic patientsFemale patientsSMILE
Systolic dysfunctionNone
Asymptomatic patients
(Hall AS, 1997)ramipril603NRNRFemale patientsAIRE
CHF unspecifiedDiabetic patients
Symptomatic patients
(Bulpitt CJ, 1998)captopril, cilazapril36712 wkNRVery old (Age 80+) patientsCilazapril/Captopril Multicentre Group
CHF unspecifiedFemale patients
Symptomatic patients
(Captopril-Digoxin Multicenter Research Group, 1988)captopril3006 moNRVery old (Age 80+) patientsCaptopril-Digoxin Multicenter Research Group
Systolic dysfunctionFemale patients
Symptomatic patients
(Swedberg K, 1999)enalapril253NRNRFemale patientsCONSENSUS
Systolic dysfunction
Symptomatic patients
(Kjekshus J, 1989)enalapril253NRRenal failure patientsVery old (Age 80+) patientsCONSENSUS
Systolic dysfunctionFemale patients
Symptomatic patientsDiabetic patients
(CONSENSUS, 1987)enalapril253NRNRFemale patientsCONSENSUS
CHF unspecifiedDiabetic patients
Symptomatic patients
(Jerie P, 1997)spirapril24812 wkNRFemale patientsCASSIS
CHF unspecified
Symptomatic patients
(Widimsky J, 1995)spirapril24812 wkNRFemale patientsCASSIS
Systolic dysfunctionDiabetic patients
Symptomatic patients
(van Veldhuisen DJ, 1998)imidapril24412 wkNRFemale patients
Systolic dysfunction
Symptomatic patients
(Brown EJ Jr, 1995)fosinopril24124 wkNRBlack patientsFosinopril Heart Failure Study Group
Systolic dysfunctionFemale patients
Symptomatic patients
(Gustafsson I, 1999)trandolapril237NRDiabetic patientsFemale patientsTRACE
Systolic dysfunction
Symptomatic patients
(Pflugfelder PW, 1993)quinapril22416 wkNRFemale patients
Systolic dysfunction
Symptomatic patients
(Gundersen T, 1995)ramipril22312 wkNRFemale patientsRamipril Multicentre Study
Systolic dysfunction
Symptomatic patients
(Giles TD, 1990)lisinopril19312 wkNRNo subpopulationslisinopril HF group
CHF unspecified
Symptomatic patients
(Kleber FX, 1992)captopril170NRNRFemale patientsMunich Mild Heart Failure
CHF unspecified
Symptomatic patients
(Ghose JC, 1993)captopril1536 moOtherFemale patients
CHF unspecified
Symptomatic patients
(Barabino A, 1991)captopril150NR moNursing homeVery old (Age 80+) patients
CHF unspecifiedNursing home patients
Symptomatic patients
(Chalmers JP, 1987)lisinopril13012 wkNRBlack patients
CHF unspecifiedFemale patients
Symptomatic patients
(Newman TJ, 1988)captopril105NRNRBlack patientsCaptopril Multicenter Research Group
Systolic dysfunctionFemale patients
Symptomatic patients
(Magnani B , 1988)captopril946 moNRFemale patients
CHF unspecified
Symptomatic patients
(Magnani B, 1986)captopril946 moNRFemale patients
CHF unspecified
Symptomatic patients
(Kleber FX, 1987)captopril59NRNRNR
CHF unspecified
Symptomatic patients
(Keren G, 1994)captopril501 yrNRFemale patients
Systolic dysfunction
Symptomatic patients
(Pouleur HG, 1993)enalapril4912 moNRFemale patientsSOLVD
Systolic dysfunction
Asymptomatic patients
(Sharpe DN, 1984)enalapril363 moNRVery old (Age 80+) patients
CHF unspecified
Symptomatic patients
(Bussmann WD, 1987)captopril236 moNRNo subpopulations
CHF unspecified
Symptomatic patients
(Creager MA, 1985)enalapril2312 wkNRNR
Systolic dysfunction
Symptomatic patients

From: Evidence Tables

Cover of Pharmacologic Management of Heart Failure and Left Ventricular Systolic Dysfunction
Pharmacologic Management of Heart Failure and Left Ventricular Systolic Dysfunction: Effect in Female, Black, and Diabetic Patients, and Cost-Effectiveness.
Evidence Reports/Technology Assessments, No. 82.
Shekelle P, Morton S, Rich M, et al.

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