Evidence Table 8. Studies associating cognitive & neurological development with malnourished patients compared to well-nourished control subjects in developing countries Part III

Author, YearPotential biasesComments
Bartel, 1978, 1979 78180773 79162492No data on difference of number of children between two reportsSingle tester blinded to child's group assignment for Bartel 1978; partially funded by African Medical Research Council
Evans, 1980 810089121 child died in each of the controls, sex unknGp1 received supplements until mean 28 months, one examiner blinded to subject's group status, testing 6–7 years after cessation of supplements; US government & South African Medical Research Council
Galler, 1983a, 1985b 83136873 85241833Withdraws/non-participation - 4 refused consent, 7 LTF, 1 cerebral palsy; Severe PEMRelevant WISC subtests utilized & some items altered for cultural setting; findings of dominant hand performance of fine motor skill tasks deficient in formerly malnourished children correlates or co-varies with IQ & other soft neurologic signs; private & hospital funded
Grantham-McGregor, 1987, 1978, 1980, 1982, 1983 87117313 79086701 81051042 82236679 83246270Controls had better housing than other 2 groups in spite of attempts to match; 2 died & 1 WD from intervention group, 1 from nonintervention moved & 1 was adopted by middle-class family, 1 from control WD; 10 of 21 Gp1 had edema, 4 of 18 in Gp2, & none in the control groupTester blinded to subjects' group, controls hospitalized mainly for gastroenteritis & respiratory infections; government & private funding
Agarwal, 1992 92372206ND on 17 of 650 in cohort; 5.5% of population were normal for growth at 24 months corresponding to 5.9% for 1989-90.Funded by Indian Council of Medical Research
Drewett, 2001 21174599Initial weight a proxy for birth weight as most births at home; 27 of 40 early wt faltering group recruited & tested; significant higher proportion of males in Gp2 vs. Gp1, χ2 = 5.56, p < .05; 6 cases (Gp1–2 & Gp2–4) with lower limb disabilities could not participate in psychomotor testSample subset of Jimma Birth Cohort study; Gp2 & Controls selected at random from sampling frame; systematic method for selection of broad comparisons for Control group; testers blinded to child's status; Private & hospital funded

From: Evidence Tables

Cover of Criteria for Determining Disability in Infants and Children: Failure to Thrive
Criteria for Determining Disability in Infants and Children: Failure to Thrive.
Evidence Reports/Technology Assessments, No. 72.
Perrin EC, Frank DA, Cole CH, et al.

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