Evidence Table 4. Studies associating immunologic response or infectious diseases with malnourished patients compared to wellnourished control subjects in developing countries Part I

Author, Year, UIDemographicsMaternal / household demographicsInclusion criteriaExclusion criteriaDefinition of malnutritionStudy design
Ferguson, 1974 75022280Country: GhanaNDSevere protein-calorie malnutritionNDSevere protein-calorie malnutritionProspective cross-sectional
Setting: Cases - inpatientControls - “normal”, matched for age
Controls - ND
Gp Ctrl
Mean age(mo)28.9(12–48)38.8(24–55)
Wt/ageNDND
Ht/lengthNDND
Enrolled/Eval1010
% MaleNDND
RaceNDND
Neumann, 1975 75106463Country: GhanaNDSee Definition of FTTNDGp1: 51–60% of 50th percentile Harvard Std for American children & albumin < 2.5 g/100ml, Gp2: 71–80% of Harvard Std & albumin > 2.5 g/100mlProspective cross-sectional
Setting: hospital/in & outpatient clinicControls matched for age, = 81% Harvard Std, nl serum albumin, no signs of malnutrition
Age: 6 mo – 6 y
Wt/age: ND
Ht/length: ND
Gp1* Gp2† Ctrl
Enrolled/Eval344241
% Male625044
Race: Africans (assumed black)
* Severely malnourished: kwashiorkor(23) & marasmus(11), † Moderately malnourished
Tuck, 1979 79254720Country: Australia & IndonesiaNDNDImmunological deficiencies in normal children attending hospital in one siteNAProspective cross-sectional
Setting: Hospital(Patients classified according to Wellcome Working Party: underweight - 60–80% SWFA, marasmic - < 60% SWFA)
Setting: Hospital
Age(mo): ND
Wt/age: ND
Ht/length: ND
Enrolled/Eval:
Gp1 marasmic 21
Gp2 underweight 23
Gp3 normal 25
% Male: ND
Race: ND
Friedland, 1992 93159117Country: South AfricaNDChildren w/kwashiorkor, marasmus, marasmic kwashiorkor admitted, ages 2 – 84 moNDWellcome criteria with growth charts from NCHSProspective cross-sectional
Setting: InpatientControls - “well-nourished & children w/nutritional growth retardation admitted during same time period”, same age range
Gp Ctrl
Age(mo)1112
Enroled/Eval15827282
% MaleNDND
Race: ND (assumed all black)
Ballard, 1995 95239862Country: KenyaMaternal reading level - average 3.5 yrs of schooling14–25 mo, free from lower respiratory infections for = 4 wksNDGp1 - ht/age < 90% of medianProspective longitudinal cohort
Setting: Rural village/ community outreachControls - “normal;”Gp2 - ht/age 90% to <95% of medianFollowed for max of 12 mos
Mean age*: 19.2 m (17.7–25.1)
Wt/age: ND
Ht/length: ND
Enrolled: 114
Evaluated† Gp1 Gp2 Ctrl
275131
49% Male (enrollment)
Race: 100% Black Africans
* At enrollment, † Gp1 Mod-severe malnutrition, Gp2 Mild malnutrition
Pandey, 1996 97246349Country: IndiaNDRandom selection of < 5 yNDGraded nutritional status as GrI though GrIV clinically & by wt/ageProspective longitudinal
Setting: OutpatientAssessments @ 2 wks for 1 y
Age(mo): Range 0–59, Mode 24–35
Enrolled: 200 households
Evaluated:
Gr1 GrII GrIII GrIV NI
375618485
% Male: ND
Race: ND

From: Evidence Tables

Cover of Criteria for Determining Disability in Infants and Children: Failure to Thrive
Criteria for Determining Disability in Infants and Children: Failure to Thrive.
Evidence Reports/Technology Assessments, No. 72.
Perrin EC, Frank DA, Cole CH, et al.

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