Evidence Table 3. Studies associating immunologic response or infectious diseases with Failure to Thrive patients compared to healthy control subjects in developed countries76 Part III

Author, YearAssociations foundPotential biasesComments
Carvalho, 1984 85145406The values for phagocytosis response and chemotactic function were significantly lower for the malnourished children in 3 tests: Zymosan incubated in Eagle, incubated with pooled normal human serum & incubated with serum from patient. The values were not significant for total complement, C3 and C4 components.Cases and controls from different hospitals serving different SES groups; no data on age matchingPhagocytosis tests on 20 children, chemotaxis on other 20, total complement on 20 chosen at random; privately funded
Sherrod, 1985 85026403NOFTT had more infections than controls during the 1st year (χ2 = 5.38, p < .025) and across all 3 years (χ2 = 5.79, p < .025). NOFTT illness were significantly increased during first 6 mo of life.Attending physicians alerted to give special treatment to children suffering from maltreatment, analysis showed no increase in outcome variability; study design to identify relationship of illness to abuse, not FTT to illnessData collectors blind to child group assignment; government & privately funded

From: Evidence Tables

Cover of Criteria for Determining Disability in Infants and Children: Failure to Thrive
Criteria for Determining Disability in Infants and Children: Failure to Thrive.
Evidence Reports/Technology Assessments, No. 72.
Perrin EC, Frank DA, Cole CH, et al.

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