Table 9Risk differences (per 10,000) for suicide and suicidality among patients with major depressive disorder.

Study, Outcome, ComparisonAbsolute Risk per 10,000, DrugAbsolute Risk, per 10,000 PlaceboRisk Difference95% CI
FDA 2006124,125
Suicide, SSRI vs. Placebo
1.79
(4/22379)
0.67
(1/14873)
1.12−1.1, 3.3
Hammad 2006137
Suicide, SSRI vs. Placebo
4.1
(6/14675)
2.3
(2/8868)
1.8−2.7, 6.3
GSK Report 2006131
Suicidal Behavior, Paroxetine vs. Placebo
31.8
(11/3455)
5.1
(1/1978)
26.85.5, 48.0
GSK Report 2006131
Suicidal Behavior or Ideation, Paroxetine
89.7
(31/3455)
55.6
(11/1978)
34.1−11.3, 79.5

From: 3, Results

Cover of Screening for Depression in Adults and Older Adults in Primary Care
Screening for Depression in Adults and Older Adults in Primary Care: An Updated Systematic Review [Internet].
Evidence Syntheses, No. 75.
O'Connor EA, Whitlock EP, Gaynes B, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.