In anticipation of the need and demand for supporting evidence and information regarding the comparative effectiveness of new regimens for chronic hepatitis C virus (HCV) infection, CADTH is updating its Therapeutic Review to include recently approved and emerging regimens for the treatment of chronic HCV infection (genotypes 1 through 6), including interferon-free regimens.

Contents

• AMENDMENT TO PROJECT PROTOCOL — May 28, 2015
• ABBREVIATIONS
• 1. BACKGROUND
• 2. PROTOCOL DEVELOPMENT
• 3. DELIVERABLES
• 4. POLICY QUESTIONS
• 5. RESEARCH QUESTIONS
• 6. METHODS
  • 6.1. Literature Search Strategy
  • 6.2. Selection Criteria
  • 6.3. Data Extraction and Critical Appraisal of Clinical Studies
  • 6.4. Data Analysis and Synthesis
  • 6.5. Opportunities for Stakeholder Feedback
  • 6.6. Data Availability
• REFERENCES
• APPENDIX 1. REGIMENS ELIGIBLE FOR INCLUSION

Suggested citation:

Drugs for chronic hepatitis C infection — project protocol. Ottawa: CADTH; 2015 Apr. (CADTH Therapeutic Review vol.3, no.1a)

This report was prepared by CADTH in collaboration with the Canadian Institutes of Health Research (CIHR) Drug Safety and Effectiveness Network (DSEN). This report contains a comprehensive review of existing public literature, studies, materials, and other information and documentation (collectively the “source documentation”) available to CADTH at the time it was prepared, and it was guided by expert input and advice throughout its preparation.

The information in this report is intended to help health care decision-makers, patients, health care professionals, health systems leaders, and policy-makers make well-informed decisions and thereby improve the quality of health care services. The information in this report should not be used as a substitute for the application of clinical judgment in respect to the care of a particular patient or other professional judgment in any decision-making process, nor is it intended to replace professional medical advice. While CADTH has taken care in the preparation of this report to ensure that its contents are accurate, complete, and up-to-date, CADTH does not make any guarantee to that effect. CADTH is not responsible for any errors or omissions or injury, loss, or damage arising from or as a result of the use (or misuse) of any information contained in or implied by the information in this report. CADTH takes sole responsibility for the final form and content of this report. The statements, conclusions, and views expressed herein do not necessarily represent the view of Health Canada or any provincial or territorial government.

Production of this report is made possible through a financial contribution from Health Canada and CIHR-DSEN.