Table 5Sensitivity and specificity of CT colonography (CTC)

Reference standardSensitivity per-patientSpecificity per-patientTotal positivity RateReferral Rate for colonoscopy
3D measurements
Pickhardt 2003 136 (n=1233)Segmentally unblinded optical colonoscopy; oral contrast; fecal tagging; 1.25–2.5 mm collimation.
adenoma ≥ 10 mm93.8% [82.8–98.7]96.0% [94.8–97.1]7.5% [6.1–9.1]1 out of every 13 screened
adenoma ≥ 8 mm93.9% [86.3–98.0]92.2% [90.5–93.7]13.5% [11.7–15.6]1 out of every 7 screened
adenoma ≥ 6 mm88.7% [82.9–93.1]79.6% [77.0–82.0]29.7% [27.1–32.3]1 out of every 3 screened
Kim 2007 137 (n=96)Segmentally unblinded optical colonoscopy; IV contrast; no fecal tagging; 2 mm collimation.
polyp ≥ 10 mm100% [100–100] (calc)100% [100–100] (calc)9.9% [5.7–14.1] (calc)1 out of every 10 screened
polyp ≥ 8 mm88.5% [76.2–100] (calc)98.5% [96.2–100] (calc)13.5% [8.7–18.4] (calc)1 out of every 7 screened
polyp ≥ 6 mm75% [62.2–87.8] (calc)94% [90.1–97.8] (calc)21.9% [16.0–27.7] (calc)1 out of every 5 screened
Johnson 2007 138 (n=452)Video optical colonoscopy; no contrast; no fecal tagging; 1.25 mm collimation presented here.
adenoma ≥ 10 mm (1.25mm slice)73% [56.0–90.1] (calc)98% [96.2–99.1] (calc)3.2% [2.0–4.3] (calc)Not calculated*
adenoma 6–9 mm (1.25mm slice)60% [42.5–77.5] (calc)94% [92.0–96.5] (calc)4.6% [3.3–6.0] (calc)Not calculated*
2D measurements
Pickhardt 2007 151 (n=730)Segmentally unblinded optical colonoscopy; oral contrast; fecal tagging; 1.25–2.5 mm collimation.
polyp ≥ 10 mm63.4% [48.7–78.2]98.1% [97.1–99.1]5.3% (calc)1 out of every 19 screened
polyp ≥ 6 mm43.0% [35.0–50.9]95.2% [93.4–96.9]12.6% (calc)1 out of every 8 screened
Kim 2007 137 (n=96)Segmentally unblinded optical colonoscopy; IV contrast; no fecal tagging; 2 mm collimation.
polyp ≥ 10 mm100% [100–100] (calc)99.5% [100–100] (calc)9.9% [5.7–14.1] (calc)1 out of every 10 screened
polyp ≥ 8 mm92% [82.1–102.6] (calc)98.5% [96.2–100.2] (calc)14.1% [9.1–19.0] (calc)1 out of every 7 screened
polyp ≥ 6 mm61.5% [47.0–75.8] (calc)90% [85.0–94.7] (calc)21.9% [16.0–27.7] (calc)1 out of every 5 screened
Johnson 2007 138 (n=452)Video optical colonoscopy; no contrast; no fecal tagging; 1.25 mm collimation presented here.
adenoma ≥ 10 mm (1.25mm slice)76% [59.3–92.7] (calc)98% [96.8–99.4] (calc)3.0% [1.9–4.1] (calc)Not calculated*
adenoma 6–9 mm (1.25mm slice)53% [35.5–71.2] (calc)95% [93.2–97.3] (calc)4.0% [2.7–5.2] (calc)Not calculated*
*

Polyp prevalence significantly different than those reported in similar studies.

From: 3, Key Questions & Results

Cover of Screening for Colorectal Cancer: An Updated Systematic Review
Screening for Colorectal Cancer: An Updated Systematic Review [Internet].
Evidence Syntheses, No. 65.1.
Whitlock EP, Lin J, Liles E, et al.

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