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Antibiotic Prophylaxis in Patients with Orthopedic Implants Undergoing Dental Procedures: A Review of Clinical Effectiveness, Safety, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Feb 17.

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Antibiotic Prophylaxis in Patients with Orthopedic Implants Undergoing Dental Procedures: A Review of Clinical Effectiveness, Safety, and Guidelines [Internet].

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CONTEXT AND POLICY ISSUES

Oral antibiotics are often used prophylactically in patients undergoing invasive dental procedures, with the aim of preventing oral bacteria from entering the bloodstream, and causing serious complications due to infection among susceptible patients.1,2

Patients with prosthetic joints have historically been prescribed antibiotics prior to dental procedures.3 A 2014 survey found that 71% of Canadian dentists and 77% of orthopedic surgeons routinely prescribed prophylactic antibiotics for patients with total join arthroplasty prior to dental procedures.3 While this practice has been commonplace, it has been carried out with little supporting clinical evidence.1,2,4 Individuals who have undergone total joint replacement are considered to be at a generally higher risk of developing infection.1 Given the frequency with which dental procedures are performed, the potential for antimicrobial resistance, and potential cost, clinical effectiveness should be demonstrated.1

The present review was conducted as an update to a 2013 CADTH Rapid Response report4 on the same topic. The 2013 report identified one guideline that recommended practitioners could consider ceasing the routine use of antibiotics prior to dental procedures for patients with prosthetic joints. This review will seek to identify any recently published clinical evidence for the prophylactic use of oral antibiotics during dental procedures in patients with orthopedic implants and to review current evidence-based guideline recommendations for this patient group.

Copyright © 2016 Canadian Agency for Drugs and Technologies in Health.

Copyright: This report contains CADTH copyright material and may contain material in which a third party owns copyright. This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner.

Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK350598

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