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Cook D, Meade M, Guyatt G, et al. Criteria for Weaning from Mechanical Ventilation. Rockville (MD): Agency for Healthcare Research and Quality (US); 2000 Nov. (Evidence Reports/Technology Assessments, No. 23.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Cover of Criteria for Weaning from Mechanical Ventilation

Criteria for Weaning from Mechanical Ventilation.

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Appendix H. Selection Criteria for Articles About Weaning



  1. Randomized controlled trials
  2. Observational studies
  3. Non-randomized Controlled Clinical Trials
  4. Qualitative studies


  1. Intensive care units
  2. Post-anaesthetic care units


  1. Adults or
  2. Children with and endotracheal tube (including tracheostomy) who are mechanically ventilated


  1. Any ventilation or weaning strategy (mode, method, protocol, procedure, operator, timing, computer use, non-invasive ventilation, tracheostomy, holistic care,) that is geared to facilitate weaning and/or extubation .
  2. Measurement of predictors of weaning and extubation success.
  3. Measurement of predictors of duration of ventilation (in cardiac surgery and COPD patients).
  4. Miscellaneous interventions designed explicitly to facilitate weaning


Publication type

  1. Editorials
  2. Letters
  3. Consensus conference reports
  4. Position papers
  5. arrative or systematic reviews


  1. Observational studies less than 20 patients
  2. Case reports


  1. Home ventilation for adults
  2. Chronic ventilation facilities


  1. Neonates
  2. Highly specific populations (obstructive sleep apnea, Guillain Barre Syndrome, flail chest)
  3. Specific conditions (polyneuropathy of the critically ill)
  4. Ventilator associated pneumonia (prevention, diagnosis, treatment)


  1. Studies of self-extubation
  2. Studies of sedation use, neuromuscular blockade, reversal of neuromuscular blockade.
  3. Studies about fluid administration.
  4. ECMO, NO, lung-protective ventilation strategies, HFO, HFJV, PLV.
  5. Interventions initiated at the onset of mechanical ventilation except in CABG or COPD patients


  1. Studies that examine only physiologic end points


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