Apolipoproteins
| Apolipoprotein | MW | Primary Source | Lipoprotein Association | Function |
|---|---|---|---|---|
| Apo A-I | 28,000 | Liver, Intestine | HDL, chylomicrons | Structural protein for HDL, Activates LCAT |
| Apo A-II | 17,000 | Liver | HDL, chylomicrons | Structural protein for HDL, Activates hepatic lipase |
| Apo A-IV | 45,000 | Intestine | HDL, chylomicrons | Unknown |
| Apo A-V | 39,000 | Liver | VLDL, chylomicrons, HDL | Promotes LPL mediated TG lipolysis |
| Apo B-48 | 241,000 | Intestine | Chylomicrons | Structural protein for chylomicrons |
| Apo B-100 | 512,000 | Liver | VLDL, IDL, LDL, Lp (a) | Structural protein, Ligand for LDL receptor |
| Apo C-I | 6,600 | Liver | Chylomicrons, VLDL, HDL | Activates LCAT |
| Apo C-II | 8,800 | Liver | Chylomicrons, VLDL, HDL | Co-factor for LPL |
| Apo C-III | 8,800 | Liver | Chylomicrons, VLDL, HDL | Inhibits LPL and uptake of lipoproteins |
| Apo E | 34,000 | Liver | Chylomicron remnants, IDL, HDL | Ligand for LDL receptor |
| Apo (a) | 250,000- 800,00 | Liver | Lp (a) | Inhibits plasminogen activation |
From: Introduction to Lipids and Lipoproteins
This electronic version has been made freely available under a Creative Commons (CC-BY-NC-ND) license. A copy of the license can be viewed at http://creativecommons.org/licenses/by-nc-nd/2.0/.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.