Box 2.9Major aspects of lipid turnover in man

Image ch2fb9.jpg

Triglycerides are absorbed from the diet in the form of chylomicrons and are only found circulating after a meal. In the post-absorptive state triglycerides are derived from very-low-density lipoprotein (VLDL) synthesized in the liver. Facilitated by high-density lipoprotein (HDL) and catalyzed by lipoprotein lipase in the capillary endothelium, free fatty acids (FFAs) are released for uptake into tissues. The triglyceride-depleted and cholesterol-enriched particles, together with the HDL, form intermediate-density lipoprotein (IDL) and remnants. The remnant particles and some of the IDL are taken up by the liver while the remainder of the IDL is converted to cholesterol-rich low-density lipoprotein (LDL) which is taken up by virtually all cells by LDL receptors.Image dclccplus.jpg , effects stimulated by insulin.

From: Chapter 2, The endocrine pancreas

Cover of Endocrinology
Endocrinology: An Integrated Approach.
Nussey S, Whitehead S.
Copyright © 2001, BIOS Scientific Publishers Limited.

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