Box 2.19Mechanism of insulin secretion and secretory response to glucose

Image ch2fb19.jpg

Entry of glucose into the β-cell induces closure of K+ channels, depolarization and opening of voltage-gated calcium channels with a consequent secretion of insulin. Other factors that modulate insulin release may act via stimulating phospholipase C (PLC) or adenyl cyclase (AC) that activate the inositol pathway or cAMP, respectively.

Abbreviations: DAG, diacyl glycerol; IP3, inositol 1,4,5-trisphosphate; PKA/C, protein kinase A/C.

Two phases of insulin secretion in response to a glucose infusion.

From: Chapter 2, The endocrine pancreas

Cover of Endocrinology
Endocrinology: An Integrated Approach.
Nussey S, Whitehead S.
Copyright © 2001, BIOS Scientific Publishers Limited.

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