TABLE 29.1

Summary of Autoantibodies and their Targets in Relation to Neurological and Nonneurological Diseases

Autoantibody IDNeuropathologyLocation of Corresponding ProteinClass of Corresponding ProteinPlace Identified (CSF, Serum)References
Anti-microtubule-associated protein tau proteinAlzheimer diseaseNerve axon, glial cells of CNSStructuralSerum, CSFBartos et al., 2012
Anti-microtubule-associated protein 2 (MAP2)PANDAS, Tourette syndrome, CNS injuryNeuronal dendriteStructuralSerumAbou-Donia et al., 2013; Morris et al., 2009
Anti-synapsin 1MSNerve terminal in CNSVesicularSerumBitsch et al., 2004; Gitlits et al., 2001
Anti-tubulin beta 3Neurological and nonneurological disordersNerve microtubuleStructuralSerum, CSFBansal et al., 2009; Op De Beeck et al., 2011
Anti-neurofilamentNeurological disorders and injuriesNerve axonStructuralSerum, CSFAbou-Donia et al., 2013; Fialova et al., 2013a; Fialova et al., 2013b; Jones et al., 2014
Anti-neuronal antibodyCerebellar damage, epilepsyNANASerumDarnell et al., 1991; Ekizoglu et al., 2014
Anti-myelin basic proteinNeuropathy, MS, and CNS injuryMyelin of nerve axonTissue antigenSerumHedegaard et al., 2009
Anti-GFAPAD, MS, and CNS injuryGlial cellsStructuralSerumEl-Fawal and McCain, 2008; Storoni et al., 2011; Zhang et al., 2014
Anti-nerve growth factorLupus, arthritis, sensorineural lossNeuronal milieuNeuronal maintenanceSerumDicou et al., 1993; Zolotova and Grebeniuk, 2010
Anti-alpha internexinNeuropsychiatric SLENerve axonStructuralSerum, CSFLu et al., 2010
Anti-NMDAMyelitis, encephalitisTransmembrane receptorSignal conductionSerum, CSFGresa-Arribas et al., 2014; Outteryck et al., 2013; Thomas et al., 2014
Anti-acetyl choline receptorSchizophrenia, myasthenia gravis, CNS injuryTransmembrane receptorSignal conductionSerumJones et al., 2014; Sorokina et al., 2011; Wang et al., 2014
Anti-desminALSNerve axonStructuralSerum, CSFNiebroj-Dobosz et al., 2006
Anti-actinSystemic autoimmune diseasesCytoskeletonStructuralSerumPorcelli et al., 2013; Zachou et al., 2012
Anti-vimentinNeurologic ischemia and systemic autoimmune diseasesCytoskeletonStructuralSerumJoachim et al., 2011; Zahran et al., 2013
Anti-MOGMS, dementiaOligodendrocyte and myelin sheathTissue antigenSerum, CSFMaetzler et al., 2011; Tsuburaya et al., 2014; Wang et al., 2008
Anti-MAGMS, autoimmune polyneuropathyMyelinating cells, myelin internodeTissue antigenSerum, CSFBaig et al., 1991; Sotgiu et al., 2009
Anti-spectrinNeurodegeneration, autoimmune diseaseCytoskeletonStructuralSerum, CSF, salivaFernandez-Shaw et al., 1997; Moody et al., 2001
Anti-GABA receptorAutism, encephalitis, neuropsychiatric SLETransmembrane receptorSignal conductionSerum, CSFMundiyanapurath et al., 2013; Tsuchiya et al., 2014; Wills et al., 2011a
Anti-glutamate receptorAutoimmune diseasesTransmembrane receptorSignal conductionSerum, CSFMurakami et al., 2013; Trippe et al., 2014

From: Chapter 29, Autoantibodies in CNS Trauma and Neuropsychiatric Disorders

Cover of Brain Neurotrauma
Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects.
Kobeissy FH, editor.
Boca Raton (FL): CRC Press/Taylor & Francis; 2015.
© 2015 by Taylor & Francis Group, LLC.

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