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Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
| Goitrogens | Agent | Action |
|---|---|---|
| Millet, soy beans | Flavonoids | Impairs thyroperoxidase |
| Cassava, sweet potato, sorghum | Cyanogenic glucosides metabolized to thiocyanates | Inhibits iodine thyroidal uptake |
| Babassu coconut | Flavoniods | Inhibits thyroperoxidase |
| Cruciferous vegetables: Cabbage, cauliflower, Broccoli, turnips | Glucosinolates | Impairs iodine thyroidal uptake |
| Seaweed (kelp) | Iodine excess | Inhibits release of thyroidal Hormones |
| Malnutrition, Iron deficiency | Vitamin A deficiency Iron deficiency | Increases TSH stimulation Reduces heme-dependent thyroperoxidase thyroidal activity |
| Selenium | Selenium deficiency | Accumulates peroxidase and cause deiodinase deficiency; impairs thyroid hormone synthesis |
Modified and adapted from Medeiros-Neto & Knobel, ref. 53 | ||
From: Multinodular Goiter
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