From: The Iodine Deficiency Disorders
This electronic version has been made freely available under a Creative Commons (CC-BY-NC-ND) license. A copy of the license can be viewed at http://creativecommons.org/licenses/by-nc-nd/2.0/.
Goitrogen | Mechanism |
Foods | |
Cassava, lima beans, linseed, sorghum, sweet potato | Contain cyanogenic glucosides; they are metabolized to thiocyanates that compete with iodine for thyroidal uptake |
Cruciferous vegetables: cabbage, kale, cauliflower, broccoli, turnips, rapeseed | Contains glucosinolates; metabolites compete with iodine for thyroidal uptake |
Soy, millet | Flavonoids impair thyroid peroxidase activity |
Nutrients | |
Selenium deficiency | Accumulated peroxides may damage the thyroid, and deiodinase deficiency impairs thyroid hormone synthesis |
Iron deficiency | Reduces heme-dependent thyroperoxidase activity in the thyroid and may blunt the efficacy of iodine prophylaxis |
Vitamin A deficiency | Increases TSH stimulation and goiter through decreased vitamin A-mediated suppression of the pituitary TSHβ gene |
From: The Iodine Deficiency Disorders
This electronic version has been made freely available under a Creative Commons (CC-BY-NC-ND) license. A copy of the license can be viewed at http://creativecommons.org/licenses/by-nc-nd/2.0/.
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