Table 4T-cell homeostasis in acute and chronic infections

  • Memory CD8 T Cells can persist and maintain their numbers in an antigen-free environment by undergoing homeostatic proliferation to replenish their pool. Homeostatic proliferation occurs in response to IL-15 and IL-7 and does not require stimulation with cognate antigen.
  • In chronic infections many pathogens can persist and provide continuous or intermittent stimulus to maintain memory T-cell numbers.

From: CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections

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