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Alberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994.

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Cover of Molecular Biology of the Cell

Molecular Biology of the Cell. 3rd edition.

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Figure 6-27. A comparison of the structures of procaryotic and eucaryotic messenger RNA molecules.

Figure 6-27A comparison of the structures of procaryotic and eucaryotic messenger RNA molecules

Although both mRNAs are synthesized with a triphosphate group at the 5' end, the eucaryotic RNA molecule immediately acquires a 5' cap, which is part of the structure recognized by the small ribosomal subunit. Protein synthesis therefore begins at a start codon near the 5' end of the mRNA (see Figure 6-24). In procaryotes, by contrast, the 5' end has no special significance, and there can be multiple ribosome-binding sites (called Shine-Dalgarno sequences) in the interior of an mRNA chain, each resulting in the synthesis of a different protein.

From: RNA and Protein Synthesis

Copyright © 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D Watson.

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