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Alberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994.

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Molecular Biology of the Cell. 3rd edition.

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Figure 6-62. DNA synapsis catalyzed by the RecA protein.

Figure 6-62DNA synapsis catalyzed by the RecA protein

In vitro experiments show that several types of complexes are formed between a DNA single strand covered with RecA protein (red) and a DNA double helix (green). First a non-base-paired complex is formed, which is converted to a three-stranded structure as soon as a region of homologous sequence is found. This complex is presumably unstable because it involves an unusual form of DNA, and it spins out a DNA heteroduplex (one strand green and the other strand red) plus a displaced single strand from the original helix (green); thus the structure shown in this diagram migrates to the left, reeling in the "input DNAs" while producing the "output DNAs." The net result is a DNA strand exchange identical to that diagrammed earlier in Figure 6-59. (Adapted from S.C. West, Annu. Rev. Biochem. 61:603-640, 1992. © Annual Reviews Inc.)

From: Genetic Recombination

Copyright © 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D Watson.


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