From: RNA Synthesis and RNA Processing
Copyright © 1994, Bruce Alberts, Dennis Bray, Julian
Lewis, Martin Raff, Keith Roberts, and James D Watson.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Alberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994.
Molecular Biology of the Cell. 3rd edition.
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Figure 8-42The common origin of bacterial and eucaryotic RNA polymerases
Amino acid sequence similarities between the β' subunit of E. coliRNA polymerase and the largest subunit of eucaryotic RNA polymerase II are among the comparisons that reveal a common evolutionary origin for the bacterial and eucaryotic enzymes. The β' subunit is thought to bind to DNA. The regions of the sequence shown as green barsare more than 70% identical between yeast and Drosophila and more than 40% identical between Drosophila and E. coli. A uniquely eucaryotic sequence (of seven amino acid residues) is repeated 26 times at the carboxyl terminus of the yeast subunit and more than 40 times in the Drosophila subunit (indicated here by green circles); these repeats are phosphorylated as part of the process that starts an RNA chain in eucaryotes (see Figure9-30). (After A.L. Greenleaf et al., in RNA Polymerase and the Regulation of Transcription [W.S. Reznikoff et al., eds.], pp. 459-464. New York: Elsevier, 1987.)
- Figure 8-42, The common origin of bacterial and eucaryotic RNA polymerases - Mol...Figure 8-42, The common origin of bacterial and eucaryotic RNA polymerases - Molecular Biology of the Cell
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