Figure 46-3. The sequence of β-amyloid precursor protein (βAPP) containing the amyloid β protein (Aβ) and transmembrane region is expanded and shown by the single-letter amino acid code.

Figure 46-3

The sequence of β-amyloid precursor protein (βAPP) containing the amyloid β protein () and transmembrane region is expanded and shown by the single-letter amino acid code. The underlined residues represent the 1–43 peptide. The broken line indicates the location of the transmembrane domain. The boxed residues depict the currently known missense mutations identified in certain patients with familial Alzheimer's disease (FAD) or hereditary cerebral hemorrhage with amyloidosis of the Dutch type (Dutch). CAA indicates that the family with a 692 Gly mutation can display congophilic amyloid angiopathy as well as Alzheimer's disease as the phenotype. Three-digit numbers refer to the residue number according to the βAPP770 isoform. Two-digit numbers refer to the Aβ sequence (Asp672 = 1).

From: Alzheimer's Disease Is the Most Common Neurodegenerative Disorder

Cover of Basic Neurochemistry
Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition.
Siegel GJ, Agranoff BW, Albers RW, et al., editors.
Philadelphia: Lippincott-Raven; 1999.
Copyright © 1999, American Society for Neurochemistry.

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