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Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001.

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Cover of Immunobiology

Immunobiology: The Immune System in Health and Disease. 5th edition.

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Figure 7.3. The early stages of B-cell development are dependent on bone marrow stromal cells.

Figure 7.3The early stages of B-cell development are dependent on bone marrow stromal cells

The upper panels show the interactions between precursor B cells and stromal cells that are required for the development to the immature B-cell stage. The designations pro-B cell and pre-B cell refer to defined phases of B-cell development as described in Fig. 7.5. Lymphoid progenitor cells and early pro-B cells bind to the adhesion molecule VCAM-1 on stromal cells through the integrin VLA-4 and also interact through other cell-adhesion molecules (CAMs). These adhesive interactions promote the binding of the receptor tyrosine kinase Kit on the surface of the pro-B cell to stem-cell factor (SCF) on the stromal cell, which activates the kinase and induces the proliferation of the B-cell progenitors. Later stages require interleukin-7 (IL-7) for proliferation and further development. Panel a: light micrograph showing small round cells, which are the B-lymphoid progenitors, in intimate contact with cultured stromal cells, which have extended processes fastening them to the plastic dish on which they are grown. Panel b: high-magnification electron micrograph of a similar cell culture in which two lymphoid cells are seen adhering to a flattened stromal cell. Photographs courtesy of A. Rolink (a); P. Kincade and P.L. Witte (b).

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