Figure 11.17. Bone marrow donor and recipient must share at least some MHC molecules to restore immune function.

Figure 11.17Bone marrow donor and recipient must share at least some MHC molecules to restore immune function

In an allogeneic bone marrow transplant, the donor marrow cells share some MHC molecules with the recipient. The shared MHC type is designated b and illustrated in blue, the MHC type of the donor marrow that is not shared is designated a and shown in yellow. Donor lymphocytes are positively selected on MHCb on thymic epithelial cells and negatively selected by the recipient stromal epithelial cells and at the cortico-medullary junction by encounter with dendritic cells derived from both the donor bone marrow and residual recipient dendritic cells. The negatively selected cells are shown as apoptotic cells. The antigen-presenting cells in the periphery can activate T cells that recognize MHCb molecules; the activated T cells can then recognize infected MHCb-bearing cells.

From: Inherited immunodeficiency diseases

Cover of Immunobiology
Immunobiology: The Immune System in Health and Disease. 5th edition.
Janeway CA Jr, Travers P, Walport M, et al.
New York: Garland Science; 2001.
Copyright © 2001, Garland Science.

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