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Movie 6Follicle stem cell clone

In the Drosophila ovary, two follicle stem cells (FSCs) reside in separate niches on opposite sides of the germarium. Daughters from each stem cell commingle and undergo several transient divisions to cover germline cysts. Despite these complexities, lineage analysis can be used to identify the stem cells and track clonally related cells over time. Here, the growth of a follicle stem cell clone (red) is shown. Note that because only one of the two FSCs acquired the label in this example, once all transient cells have washed out, 50% of the follicle cell population is labeled. In addition, it is possible to identify which follicle cells were derived from each FSC.

From: Lineage analysis of stem cells

Cover of StemBook
StemBook [Internet].
Cambridge (MA): Harvard Stem Cell Institute; 2008-.
Copyright: © 2008 D.T. Fox, L.X. Morris, T. Nystul, and A.C. Spradling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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