Table 2T-cell-APC Interactions that Regulate GVHD.

T cell costimulationT cellAPC
AdhesionICAMsLEA-1
LEA-1ICAM∼
CD2 (LEA-2)LFA-3
RecognitionTCR/CD4NIIIC hi
TCR/CD8Mi-lcc l
CostimulationCD28CD80/86
CD152 (CTLA-4)CD80/86
ICOSB7H/B7RP-1
PD-1PD-L1, PD-L2
UnknownB7-H3
CD 154 (CD4OL)CD40
CD134 (0X40)CD13L(OX40L)
CD137 (4-IBBCD137L (4-1IBBL
HVEMLIGHT

From: Mouse models of graft-versus-host disease

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Cambridge (MA): Harvard Stem Cell Institute; 2008-.
Copyright: © 2009 Pavan Reddy and James L.M. Ferrara.

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