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Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002.

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Molecular Biology of the Cell. 4th edition.

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Figure 25-5. Genetic differences between pathogens and nonpathogens.

Figure 25-5Genetic differences between pathogens and nonpathogens

Nonpathogenic Escherichia coli has a single circular chromosome. E. coli is very closely related to two types of food-borne pathogens—Shigella flexneri, which causes dysentery, and Salmonella enterica, a common cause of food poisoning. If these three organisms were being named today based on molecular techniques, they would be classified in the same genus, if not the same species. The chromosome of S. flexneri differs from that of E. coli at only a few loci; most of the genes required for pathogenesis are carried on an extrachromosomal virulence plasmid. The chromosome of S. enterica carries two large inserts (pathogenicity islands) not found in the E. coli chromosome; these inserts each contain many virulence genes.

From: Introduction to Pathogens

Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .


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