Figure 19-17. Gap junction coupling in the ovarian follicle.

Figure 19-17Gap junction coupling in the ovarian follicle

The oocyte is surrounded by a thick layer of extracellular matrix called the zona pellucida (discussed in Chapter 20). The surrounding granulosa cells are coupled to each other by gap junctions formed by connexin 43 (Cx43). In addition, the granulosa cells extend processes through the zona pellucida and make gap junctions with the oocyte. These gap junctions contain a different connexin (Cx37). Mutations in the gene encoding Cx37 cause infertility by disrupting the development of both the granulosa cells and the oocyte.

From: Cell Junctions

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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