Table 4.2

Recommendations for AED treatment for children and adults when cost is of concern

Seizures/syndromesFirst-line AEDs in order of prioritySecond-line AEDs
Focal (simple and complex) seizures with or without secondarily GTCSCarbamazepine, phenytoin, phenobarbitoneClobazam, valproate
Primarily GTCS onlyValproate, phenobarbitone, phenytoinCarbamazepine
Myoclonic seizures onlyClonazepam, phenobarbitonePhenytoin, ethosuximide
Absence seizures only (typical and atypical)Valproate, ethosuximideClonazepam
Negative myoclonic and atonic seizuresEthosuximide, valproateClonazepam
Tonic seizuresValproate, phenytoin, phenobarbitoneClonazepam, clobazam
All syndromes of focal epilepsiesCarbamazepine, phenytoin, phenobarbitoneClobazam, valproate
Childhood absence epilepsyEthosuximide, valproateClonazepam
Juvenile absence epilepsyValproate, ethosuximideClonazepam
Juvenile myoclonic epilepsyValproate, phenobarbitoneClonazepam, ethosuximide
Photosensitive seizures and other reflex seizuresMainly valproate and clonazepam In accordance with the predominant seizure
Lennox-Gastaut syndrome and other epileptic encephalopathiesIn accordance with the predominant seizure

From: Chapter 4, Principles of Therapy in Epilepsies

Cover of The Epilepsies
The Epilepsies: Seizures, Syndromes and Management.
Panayiotopoulos CP.
Oxfordshire (UK): Bladon Medical Publishing; 2005.
Copyright © 2005, Bladon Medical Publishing, an imprint of Springer Science+Business Media.

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