Box 4.32Aldosterone actions in the kidney

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In the circulation aldosterone (A) is mainly bound to cortisol-binding globulin (CBG) or albumin. Free aldosterone enters the tubule cells of the kidney and binds to the mineralocorticoid receptor (MR). This induces release of a heat shock protein (hsp), dimerization of two MRs and translocation to the nucleus where it binds to a glucocorticoid response element (GRE) on the DNA and, along with other transcription factors, initiates protein synthesis. The aldosterone-induced proteins include factors that regulate the luminal Na+ channel and components of the Na+/K+ ATPase pump. There is also evidence for rapid membrane effects of aldosterone on tubular cells.

From: Chapter 4, The adrenal gland

Cover of Endocrinology
Endocrinology: An Integrated Approach.
Nussey S, Whitehead S.
Copyright © 2001, BIOS Scientific Publishers Limited.

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