FIGURE 2.1. (See color insert following page 272.


(See color insert following page 272.) Spontaneous and electrically evoked dopamine transients from the NAc of a rat. The color plot (bottom, Michael et al. 1998) shows changes in current (color) by applied potential (y-axis) over 6 s (x-axis). The unfiltered data have been smoothed three times with a two-dimensional smooth. Fluctuations in current at the oxidation potential of dopamine, approximately 600 mV (versus Ag/AgCl reference), are shown in the trace above the color plot. A small increase in current occurs at approximately 2.5 s, and is confirmed to be due to dopamine oxidation by the cyclic voltammogram (above); this is a spontaneous dopamine transient. One second later, an electrical stimulation (indicated by the green bar; 20 Hz, 12 p, biphasic, 2 ms/phase, 125 μA) was delivered to the ventral tegmental area, producing a robust increase in dopamine release, as indicated by the cyclic voltammogram (above).

From: Chapter 2, Rapid Dopamine Release in Freely Moving Rats

Cover of Electrochemical Methods for Neuroscience
Electrochemical Methods for Neuroscience.
Michael AC, Borland LM, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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