FIGURE 14.2. Cosecretion of epinephrine and norepinephrine from an adrenal cell.

FIGURE 14.2

Cosecretion of epinephrine and norepinephrine from an adrenal cell. (a) Oxidation current (solid line), ΔE p (dotted line), and adrenochrome current (dashed line) vs. time. (b) E p (solid line), ΔE p (dotted line), and i cyc/iox (dashed line) vs. time. The scale for each of these parameters is adjusted so that the values fall between those for pure epinephrine (upper dashed line) and pure norepinephrine (lower dashed line). (c) Background-corrected cyclic voltammograms (solid line) taken at the asterisk in (a). Circles represent the background-corrected cyclic voltammogram of the epinephrine postcalibration. Voltammograms have been normalized to the oxidation peak currents. (d) Background-corrected cyclic voltammogram (solid line) taken 25 s after stimulation. Circles again are the postcalibration for norepinephrine. (Reproduced from Ciolkowski, E. L., Cooper, J. M., Jankowski, J. A., Jorgenson, J. W., Wightman, R. M., J. Am. Chem. Soc., 114, 2815–2821, 1992. With permission.)

From: Chapter 14, Electrochemistry at the Cell Membrane/Solution Interface

Cover of Electrochemical Methods for Neuroscience
Electrochemical Methods for Neuroscience.
Michael AC, Borland LM, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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