FIGURE 14.10. A more complete model of the release process during exocytosis basing on the fluorescence observations.

FIGURE 14.10

A more complete model of the release process during exocytosis basing on the fluorescence observations. This model assumes that as the vesicle opens, it has a transitory period where mass transport of catechol to the electrode is via diffusion from a frustum with opening r f defining the value of rνmiddot; Catechol diffusing to the electrode is oxidized. After exocytosis is complete, the membrane–electrode space is filled with solution from the inside of the vesicle, and catechol present continues to be oxidized as in the thin-layer representation of Figure 14.10. (Reproduced from Cans, A. S., Wittenberg, N., Eves, D., Karlsson, R., Karlsson, A., Orwar, O., Ewing, A., Anal. Chem., 75 (16), 4168–4175, 2003. With permission.)

From: Chapter 14, Electrochemistry at the Cell Membrane/Solution Interface

Cover of Electrochemical Methods for Neuroscience
Electrochemical Methods for Neuroscience.
Michael AC, Borland LM, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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