Figure 5.. Role of SUMO-targeted ubiquitin ligases in genome stability.

Figure 5.

Role of SUMO-targeted ubiquitin ligases in genome stability. Processing of stalled replication forks and double strand breaks as well as homologous recombination repair (HRR) and DNA damage repair require the action of the ULS enzymes Slx5-Slx8 in budding yeast and Rfp1,2-Slx8 in fission yeast. These types of genomic instability coincide with the appearance of increased amounts of SUMO conjugates, which can lead to an arrest in the cell division cycle if they are not sufficiently controlled by Slx5-Slx8-mediated ubiquitylation and subsequent proteasomal degradation or by desumoylation.

From: Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.