Table 1Structures of Lewis blood group antigens and glycosyltransferases required for biosynthesis

StructureAntigenGlycosyltransferases required
Fucα1→2Galβ1→3GlcNAcaH type 1α2FucT, β3GalT
Fucα1→2Galβ1→4GlcNAcbH type 2α2FucT, β4GalT
Galβ1→4GlcNAcLewis x (Lex)α3FucT, β4GalT
3
Fucα1
Fucα1→2Galβ1→4GlcNAcLewis y (Ley)α2FucT, α3FucT, β4GalT
3
Fucα1
Galβ1→3GlcNAcLewis a (Lea)α4FucT, β3GalT
4
Fucα1
Fucα1→2Galβ1→3GlcNAcLewis b (Leb)α2FucT, α4FucT, β3GalT
4
Fucα1
→3(Galβ1→4GlcNAcβ1→)ni-antigenβ4GalT
NANA2→3Galβ1→4GlcNAcSialyl Lewis x (sLex)α3FucT, β4GalT, sialylT
3
Fucα1
Fucα1→Galβ1→3GlcNAcBlood group Acα2FucT, βGalT, α3GalNAcT
3
GalNAcα1
a

Abbreviations used: Gal, d-galactose; Fuc, l-fucose; GlcNAc, N-acetyl-d-glucosamine; NANA, N-acetylneuraminic (=sialic) acid; α2/3/4FucT, α2/3/4 fucosyltransferase; β3/4GalT, β3/4 galactosyltransferase; GalNAcT, N-acetyl-d-galactosaminyltransferase; GlcNAcT, N-acetyl-d-glucosaminyltransferase. For biosynthesis of all blood group antigens shown, an active β3-GlcNAcT is also required.

b

Structural chemistry has failed to detect the presence of H type 2 epitopes in H. pylori LPS.

c

H. pylori and H. mustelae both express blood group A type 1.

From: Chapter 35, Lipopolysaccharide Lewis Antigens

Cover of Helicobacter pylori
Helicobacter pylori: Physiology and Genetics.
Mobley HLT, Mendz GL, Hazell SL, editors.
Washington (DC): ASM Press; 2001.
Copyright © 2001, ASM Press.

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