Figure 12.1. Schematic diagram of the foot-and-mouth disease virus surface proteins.

Figure 12.1

Schematic diagram of the foot-and-mouth disease virus surface proteins. Each of the three main surface proteins, VP1, VP2, and VP3, fills a trapezoidal space with eight β chains (arrows) labeled B-I and two α chains (cylinders). The loops connecting the β chains tend to be exposed on the protein surface, sometimes protruding from the protein core. The two-letter codes for the loops name the connected β chains. The carboxyl (HOOC) and amino (NH2) termini may also occur at the surface. Antibodies apparently interact mainly with the loops and termini. The three proteins differ in the location and exposure of various loops, as indicated in fig. 12.2. Redrawn from Haydon and Woolhouse (1998) based on original work in Harrison (1989, with permission from Nature, www.nature.com).

From: Chapter 12, Experimental Evolution: Foot-and-Mouth Disease Virus

Cover of Immunology and Evolution of Infectious Disease
Immunology and Evolution of Infectious Disease.
Frank SA.
Princeton (NJ): Princeton University Press; 2002.
Copyright © 2002, Steven A Frank.

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