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Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens

A Workshop Summary


Washington (DC): National Academies Press (US); .
ISBN-10: 0-309-09700-2


Toxicogenomics is described as a discipline combining expertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environments. As this emerging field rapidly develops, it is important to assess how toxicogenomic data can be applied to improve risk assessment, particularly for carcinogens. The Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals designed a workshop to identify critical knowledge gaps in carcinogenic risk assessment and discuss the potential role of toxicogenomics in addressing these gaps. This summary of the workshop discusses current approaches to cancer risk assessment, the potential use of toxicogenomic data in this process, lessons learned from case studies on two carcinogens (1,3-butadiene and arsenic), and research that may be useful in moving the field forward.

This project was supported by Contract No. N01-OD-4-2139 between the National Academy of Sciences and the National Institute of Environmental Health Sciences. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

Copyright © 2005, National Academy of Sciences.
Bookshelf ID: NBK23734PMID: 20669455DOI: 10.17226/11335


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